Molecular structure of 2-Oxo clopidogrel hydrochloride, CAS Number: 1219432-42-4
2-Oxo clopidogrel hydrochloride (CAS 1219432-42-4)
See product citations (5)
Alternate Names:
α-(2-Chlorophenyl)-2,6,7,7a-tetrahydro-2-oxo-thieno[3,2-c]pyridine-5(4H)-acetic Acid Methyl Ester Hydrochloride
Application:
2-Oxo clopidogrel hydrochloride is an essential metabolite
CAS Number:
1219432-42-4
Molecular Weight:
374.28
Molecular Formula:
C16H17Cl2NO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2-Oxo Clopidogrel Hydrochloride(Mixture of Diastereomers) is a diasteromeric preparation of a main metabolite of Clopidogrel (sc-203553), a potent inhibitor of ADP-induced platelet aggregation. This metabolite is oxidized next to the sulfur on the thioenopyridine portion of the compound.
2-Oxo clopidogrel hydrochloride (CAS 1219432-42-4) References
- Antiplatelet action of R-99224, an active metabolite of a novel thienopyridine-type G(i)-linked P2T antagonist, CS-747. | Sugidachi, A., et al. 2001. Br J Pharmacol. 132: 47-54. PMID: 11156560
- Importance of hepatic metabolism in the antiaggregating activity of the thienopyridine clopidogrel. | Savi, P., et al. 1992. Biochem Pharmacol. 44: 527-32. PMID: 1510701
- In vitro biotransformation studies of 2-oxo-clopidogrel: multiple thiolactone ring-opening pathways further attenuate prodrug activation. | Zhu, Y. and Zhou, J. 2013. Chem Res Toxicol. 26: 179-90. PMID: 23249383
- P-Glycoprotein Polymorphism C3435T Is Associated with Dose-Adjusted Clopidogrel and 2-Oxo-Clopidogrel Concentration. | Stokanovic, D., et al. 2016. Pharmacology. 97: 101-6. PMID: 26695516
- The Metabolism of Clopidogrel: CYP2C19 Is a Minor Pathway. | Ford, NF. 2016. J Clin Pharmacol. 56: 1474-1483. PMID: 27196064
- Validation of a method for quantitation of the clopidogrel active metabolite, clopidogrel, clopidogrel carboxylic acid, and 2-oxo-clopidogrel in feline plasma. | Lyngby, JG., et al. 2017. J Vet Cardiol. 19: 384-395. PMID: 28602635
- Development of an LC-MS/MS method for determination of 2-oxo-clopidogrel in human plasma. | Li, YH., et al. 2015. J Pharm Anal. 5: 12-17. PMID: 29403910
- The association of clopidogrel and 2-oxo-clopidogrel plasma levels and the 40 months clinical outcome after primary PCI. | Pavlovic, M., et al. 2018. Int J Clin Pharm. 40: 1482-1489. PMID: 30367373
- Broad spectrum anti-platelet activity of ticlopidine and PCR 4099 involves the suppression of the effects of released ADP. | Féliste, R., et al. 1987. Thromb Res. 48: 403-15. PMID: 3127924
- Simultaneous determination of clopidogrel, 2-oxo-clopidogrel, and the thiol metabolite of clopidogrel in human plasma by LC-MS/MS. | Xu, L., et al. 2022. J Biomed Res. 36: 109-119. PMID: 35387902
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Oxo clopidogrel hydrochloride, 2.5 mg | sc-209242A | 2.5 mg | $214.00 | |||
2-Oxo clopidogrel hydrochloride, 5 mg | sc-209242 | 5 mg | $347.00 | |||
2-Oxo clopidogrel hydrochloride, 10 mg | sc-209242B | 10 mg | $612.00 | |||
2-Oxo clopidogrel hydrochloride, 50 mg | sc-209242C | 50 mg | $2448.00 |