2-O-ethyl PAF C-16 (CAS 78858-42-1)

2-O-ethyl PAF C-16, a synthetic derivative of platelet-activating factor (PAF), has gained significant attention in scientific research for its role in elucidating the molecular mechanisms underlying PAF receptor activation and downstream signaling pathways. One crucial mechanism of action involves its interaction with PAF receptors, particularly subtype 1 (PAF-R1), leading to the modulation of intracellular signaling cascades. Studies have shown that 2-O-ethyl PAF C-16 acts as a potent agonist or antagonist of PAF receptors, depending on the specific cellular context and receptor subtype. Upon binding to PAF receptors, 2-O-ethyl PAF C-16 triggers a series of signaling events that regulate various cellular processes, including inflammation, immune response, and vascular permeability. Furthermore, researchers have utilized 2-O-ethyl PAF C-16 as a molecular probe to investigate the physiological and pathological roles of PAF receptors in diverse biological systems, such as cardiovascular function, respiratory disorders, and neuroinflammation. Additionally, the development of 2-O-ethyl PAF C-16 analogs and derivatives has facilitated the exploration of structure-activity relationships and pharmacological properties, providing insights into potential interventions targeting PAF receptor-mediated pathways. Overall, 2-O-ethyl PAF C-16 remains a valuable tool in research aimed at unraveling the complexities of PAF signaling and its implications in health and disease.