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2-Nitrofluorene (CAS 607-57-8)

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Alternate Names:
2-Nitro-9H-fluorene
Application:
2-Nitrofluorene is a nitrated polycyclic aromatic hydrocarbon
CAS Number:
607-57-8
Purity:
≥97%
Molecular Weight:
211.22
Molecular Formula:
C13H9NO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Nitrofluorene is a nitrated polycyclic aromatic hydrocarbon 2-Nitrofluorene, an organic compound of great significance in the chemical industry, boasts a remarkable versatility that renders it highly valuable across various applications. In scientific research, 2-Nitrofluorene has proven its worth as a valuable reagent in organic synthesis and a key starting material for the creation of other compounds. It also serves as a fluorescent label for proteins, facilitating their study, and acts as a biochemical probe, shedding light on enzyme activity. Furthermore, researchers have effectively utilized 2-Nitrofluorene as a model to investigate the effects of nitro compounds on biological systems. Understanding the mechanism of action of 2-Nitrofluorene remains an ongoing pursuit. Nevertheless, it is believed that the compound interacts with biological molecules through multiple mechanisms, including hydrogen bonding, hydrophobic interactions, and electrostatic interactions. Additionally, the potential for covalent bonding with biological molecules further contributes to its intriguing properties. As this remarkable compound continues to pave the way for advancements in various scientific disciplines, future research directions for 2-Nitrofluorene are being explored, holding promise for exciting discoveries and innovations in the field.


2-Nitrofluorene (CAS 607-57-8) References

  1. Metabolism of 2-nitrofluorene, 2-aminofluorene and 2-acylaminofluorenes in rat and dog and the role of intestinal bacteria.  |  Ueda, O., et al. 2001. Xenobiotica. 31: 33-49. PMID: 11339231
  2. Metabolism of 2-nitrofluorene, an environmental pollutant, by liver preparations of sea bream, Pagrus major.  |  Ueda, O., et al. 2002. Xenobiotica. 32: 667-82. PMID: 12296988
  3. Xanthine oxidase-catalyzed metabolism of 2-nitrofluorene, a carcinogenic air pollutant, in rat skin.  |  Ueda, O., et al. 2003. Drug Metab Dispos. 31: 367-72. PMID: 12642461
  4. Bioactivation of 2-nitrofluorene to reactive intermediates that bind covalently to DNA, RNA and protein in vitro and in vivo in the rat.  |  Wierckx, FC., et al. 1990. Carcinogenesis. 11: 27-32. PMID: 1688520
  5. 2-Nitrofluorene metabolism in the rat lung. Pharmacokinetic and metabolic effects of beta-naphthoflavone treatment.  |  Törnquist, S., et al. 1990. Carcinogenesis. 11: 1249-54. PMID: 2387010
  6. 2-nitrofluorene.  |  . 1989. IARC Monogr Eval Carcinog Risks Hum. 46: 277-89. PMID: 2697768
  7. The air pollutant 2-nitrofluorene as initiator and promoter in a liver model for chemical carcinogenesis.  |  Möller, L., et al. 1989. Carcinogenesis. 10: 435-40. PMID: 2924391
  8. 2-Nitrofluorene and related compounds: prevalence and biological effects.  |  Beije, B. and Möller, L. 1988. Mutat Res. 196: 177-209. PMID: 3047568
  9. Theoretical studies on the photochemistry of 2-nitrofluorene in the gas phase and acetonitrile solution.  |  Li, B., et al. 2020. Phys Chem Chem Phys. 22: 16772-16782. PMID: 32662496
  10. Effects of secondary biliary acids on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine, 2-acetylaminofluorene and 2-nitrofluorene towards Salmonella typhimurium strains.  |  Wilpart, M. and Roberfroid, M. 1986. Carcinogenesis. 7: 703-6. PMID: 3516434
  11. Endocrine-disrupting metabolic activation of 2-nitrofluorene catalyzed by human cytochrome P450 1A1: A QM/MM approach.  |  Zhou, J., et al. 2022. Environ Int. 166: 107355. PMID: 35751956
  12. Identification of 2-nitrofluorene in diesel exhaust particulates.  |  Xu, XB., et al. 1981. J Appl Toxicol. 1: 196-8. PMID: 6193162
  13. Derivatives of 2-nitrofluorene cause changes of human sperm motility.  |  Leijonhufvud, PK., et al. 1994. Pharmacol Toxicol. 75: 310-4. PMID: 7870703

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Nitrofluorene, 5 g

sc-230598
5 g
$56.00