Date published: 2026-5-17

1-800-457-3801

SCBT Portrait Logo
Seach Input

2-Methylthioadenosine Triphosphate Sodium Salt (CAS 100020-57-3)

5.0(1)
Write a reviewAsk a question

Alternate Names:
2-(methylthio)-adenosine-s′-(tetrahydrogen triphosphate) sodium salt
Application:
2-Methylthioadenosine Triphosphate Sodium Salt is an ATP analogue which acts as a P2Y agonist
CAS Number:
100020-57-3
Molecular Weight:
641.20
Molecular Formula:
C11H14N5O13P3S•4Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

2-Methylthioadenosine Triphosphate Sodium Salt is an ATP analogue, which acts as a P2Y agonist. Studies involving rat smooth muscle indicate that 2-Methylthioadenosine Triphosphate Sodium Salt causes a concentration dependent relaxation. The compound displays an EC50= 240 nM in rat smooth muscle. P2Y receptors are G-coupled protein receptors, which functions as a mediator of vasorelaxtion as a result of nitric oxide production. Furthermore, 2-Methylthioadenosine Triphosphate Sodium Salt and extracellular ATP can influence glomerular haemodynamics through the activation of P2 receptors located on its cell surface.


2-Methylthioadenosine Triphosphate Sodium Salt (CAS 100020-57-3) References

  1. Cyclic GMP-dependent relaxation of isolated rat renal glomeruli induced by extracellular ATP.  |  Jankowski, M., et al. 2001. J Physiol. 530: 123-30. PMID: 11136864
  2. P2y1 and P2y2 receptor-operated Ca2+ signals in primary cultures of cardiac microvascular endothelial cells.  |  Moccia, F., et al. 2001. Microvasc Res. 61: 240-52. PMID: 11336535
  3. Effects of purinoceptor agonists on electrophysiological properties of rat mesencephalic trigeminal neurones in vitro.  |  Regenold, JT., et al. 1988. Neurosci Lett. 92: 347-50. PMID: 3200490
  4. Studies on the stereoselectivity of the P2-purinoceptor.  |  Burnstock, G., et al. 1983. Br J Pharmacol. 79: 907-13. PMID: 6317121
  5. Specific but noncompetitive inhibition by 2-alkylthio analogues of adenosine 5'-monophosphate and adenosine 5'-triphosphate of human platelet aggregation induced by adenosine 5'-diphosphate.  |  Cusack, NJ. and Hourani, SM. 1982. Br J Pharmacol. 75: 397-400. PMID: 7186826
  6. Expression of a cloned P2Y purinergic receptor that couples to phospholipase C.  |  Filtz, TM., et al. 1994. Mol Pharmacol. 46: 8-14. PMID: 8058061
  7. Differential heterologous and homologous desensitization of two receptors for ATP (P2y purinoceptors and nucleotide receptors) coexisting on endothelial cells.  |  Wilkinson, GF., et al. 1994. Mol Pharmacol. 45: 731-6. PMID: 8183253
  8. Heterogeneity of ATP receptors in aortic endothelial cells. Involvement of P2y and P2u receptors in inositol phosphate response.  |  Motte, S., et al. 1993. Circ Res. 72: 504-10. PMID: 8431980
  9. Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor.  |  Schachter, JB., et al. 1996. Br J Pharmacol. 118: 167-73. PMID: 8733591
  10. Identification of competitive antagonists of the P2Y1 receptor.  |  Boyer, JL., et al. 1996. Mol Pharmacol. 50: 1323-9. PMID: 8913364
  11. Regulation of brain capillary endothelial cells by P2Y receptors coupled to Ca2+, phospholipase C and mitogen-activated protein kinase.  |  Albert, JL., et al. 1997. Br J Pharmacol. 122: 935-41. PMID: 9384512
  12. Control of massive prostatic bleeding with angiographic techniques.  |  Mitchell, ME., et al. 1976. J Urol. 115: 692-5. PMID: 940204
  13. Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate.  |  Boyer, JL., et al. 1998. Br J Pharmacol. 124: 1-3. PMID: 9630335

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Methylthioadenosine Triphosphate Sodium Salt, 10 mg

sc-202910
10 mg
$620.00