Molecular structure of 2-Methylthioadenosine 5′-monophosphate triethylammonium salt, CAS Number: 22140-20-1 (non-salt)
2-Methylthioadenosine 5′-monophosphate triethylammonium salt (CAS 22140-20-1 (non-salt))
Alternate Names:
2-MeSAMP
Application:
2-Methylthioadenosine 5′-monophosphate triethylammonium salt is a P2Y(AC) antagonist
CAS Number:
22140-20-1 (non-salt)
Molecular Weight:
393.31 (anhydrous free acid basis)
Molecular Formula:
C11H16N5O7PS•xC6H15N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2-Methylthioadenosine 5′-monophosphate triethylammonium salt is the only known preferential antagonist for the P2Y(AC) receptor. The platelet ADP receptor that is coupled to adenyl cyclase. It is also referred to as the P2Y ADP receptor.
2-Methylthioadenosine 5′-monophosphate triethylammonium salt (CAS 22140-20-1 (non-salt)) References
- Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling. | Zhang, G., et al. 2011. J Biol Chem. 286: 39466-77. PMID: 21940635
- Short-acting P2Y12 blockade to reduce platelet dysfunction and coagulopathy during experimental extracorporeal circulation and hypothermia. | Krajewski, S., et al. 2012. Br J Anaesth. 108: 912-21. PMID: 22369765
- Blood clots are rapidly assembled hemodynamic sensors: flow arrest triggers intraluminal thrombus contraction. | Muthard, RW. and Diamond, SL. 2012. Arterioscler Thromb Vasc Biol. 32: 2938-45. PMID: 23087356
- The P2Y(12) antagonists, 2MeSAMP and cangrelor, inhibit platelet activation through P2Y(12)/G(i)-dependent mechanism. | Xiang, B., et al. 2012. PLoS One. 7: e51037. PMID: 23236426
- Calcium mobilization and protein kinase C activation downstream of protease activated receptor 4 (PAR4) is negatively regulated by PAR3 in mouse platelets. | Arachiche, A., et al. 2013. PLoS One. 8: e55740. PMID: 23405206
- Detection of platelet sensitivity to inhibitors of COX-1, P2Y₁, and P2Y₁₂ using a whole blood microfluidic flow assay. | Li, R. and Diamond, SL. 2014. Thromb Res. 133: 203-10. PMID: 24365044
- Mechanism of race-dependent platelet activation through the protease-activated receptor-4 and Gq signaling axis. | Tourdot, BE., et al. 2014. Arterioscler Thromb Vasc Biol. 34: 2644-50. PMID: 25278289
- Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion. | Cooke, NM., et al. 2015. BMC Cancer. 15: 627. PMID: 26353776
- P2Y13 receptors mediate presynaptic inhibition of acetylcholine release induced by adenine nucleotides at the mouse neuromuscular junction. | Guarracino, JF., et al. 2016. Neuroscience. 326: 31-44. PMID: 27058149
- Differential integrin activity mediated by platelet collagen receptor engagement under flow conditions. | Pugh, N., et al. 2017. Thromb Haemost. 117: 1588-1600. PMID: 28536721
- Protease-Activated Receptor 4 (PAR4): A Promising Target for Antiplatelet Therapy. | Rwibasira Rudinga, G., et al. 2018. Int J Mol Sci. 19: PMID: 29443899
- The protease-activated receptor 4 Ala120Thr variant alters platelet responsiveness to low-dose thrombin and protease-activated receptor 4 desensitization, and is blocked by non-competitive P2Y12 inhibition. | Whitley, MJ., et al. 2018. J Thromb Haemost. 16: 2501-2514. PMID: 30347494
- The relation between ABO blood types and clinical and platelet function parameters in patients who underwent percutaneous coronary intervention. | Timur, AA., et al. 2019. Coron Artery Dis. 30: 51-58. PMID: 30407210
- Arachidonate metabolism, 5-hydroxytryptamine release and aggregation in human platelets activated by palmitaldehyde acetal phosphatidic acid. | Brammer, JP. and Maguire, MH. 1984. Br J Pharmacol. 82: 61-72. PMID: 6428500
- The Relative Role of Soluble Guanylyl Cylase Dependent and Independent Pathways in Nitric Oxide Inhibition of Platelet Aggregation Under Flow | J. L. Sylman, S. M. Lantvit, M. M. Reynolds & Keith B. Neeves. 2014. Cellular and Molecular Bioengineering. 421–431.
Inhibitor of:
P2Y.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Methylthioadenosine 5′-monophosphate triethylammonium salt, 5 mg | sc-213854 | 5 mg | $1200.00 |