Date published: 2026-4-27

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2-(Methylsulfonyl)ethanol (CAS 15205-66-0)

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Alternate Names:
2-Hydroxyethyl methyl sulfone
CAS Number:
15205-66-0
Molecular Weight:
124.16
Molecular Formula:
C3H8O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-(Methylsulfonyl)ethanol, known as Mesylate, is a highly versatile organic solvent widely employed in scientific research. This colorless liquid exhibits water solubility, a faint odor, and low toxicity. Its applications span across various domains, serving as a reagent in organic synthesis, a solvent for liquid-liquid extractions, and a stabilizer in enzyme reactions. Furthermore, it plays a significant role in the production of agrochemicals and industrial chemicals. In the realm of organic synthesis, 2-(Methylsulfonyl)ethanol proves invaluable as a potent base capable of forming carbon-sulfur bonds. Its water solubility also makes it a valuable solvent for liquid-liquid extractions. Additionally, it finds utility as a stabilizer in enzyme reactions, effectively mitigating enzyme denaturation by regulating the pH of the reaction mixture.


2-(Methylsulfonyl)ethanol (CAS 15205-66-0) References

  1. Achieving high dielectric constant and low loss property in a dipolar glass polymer containing strongly dipolar and small-sized sulfone groups.  |  Wei, J., et al. 2015. ACS Appl Mater Interfaces. 7: 5248-57. PMID: 25693003
  2. Effects of charge, volume, and surface on binding of inhibitor and substrate moieties to acetylcholinesterase.  |  Cohen, SG., et al. 1985. J Med Chem. 28: 1309-13. PMID: 4032433
  3. Mild conversion of electron deficient aryl fluorides to phenols using 2-(methylsulfonyl)ethanol  |  John F. Rogers, Daniel M. Green. 2002. Tetrahedron Letters. 43: 3585-3587.
  4. Synthesis of β-hydroxy sulfones via opening of hydrophilic epoxides with zinc sulfinates in aqueous media  |  Nataliya Chumachenko, Paul Sampson. 2006. Tetrahedron. 62: 4540-4548.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-(Methylsulfonyl)ethanol, 10 g

sc-237874
10 g
$100.00

2-(Methylsulfonyl)ethanol, 50 g

sc-237874A
50 g
$319.00