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2-Methylserotonin maleate salt (CAS 78263-91-9)

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Alternate Names:
3-(2-Aminoethyl)-2-methyl-1H-indol-5-ol Maleate
Application:
2-Methylserotonin maleate salt is a SR-3 / HTR3 (5-HT3 serotonin receptor) agonist
CAS Number:
78263-91-9
Molecular Weight:
306.31
Molecular Formula:
C11H14N2O•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Methylserotonin maleate salt is a compound that is frequently used in neurochemical research due to its selectivity and affinity for serotonin receptors. In studies that explore the complex pathways of neurotransmission, this chemical is useful for identifying the roles of specific serotonin receptor subtypes in neuronal signaling. Researchers also utilize 2-Methylserotonin maleate salt to understand the regulation of mood, appetite, and circadian rhythms, which are all influenced by serotonergic activity. Additionally, it serves as a probe to decipher the mechanisms underlying the modulation of the gastrointestinal tract, where serotonin plays a significant role. Its use extends to examining the binding characteristics of serotonin receptors, providing insights into receptor function and the potential design of new research tools.


2-Methylserotonin maleate salt (CAS 78263-91-9) References

  1. Study of mechanisms of calcitonin analgesia in mice. Involvement of 5-HT3 receptors.  |  Ormazábal, MJ., et al. 1999. Brain Res. 845: 130-8. PMID: 10536192
  2. Itch-associated response induced by intradermal serotonin through 5-HT2 receptors in mice.  |  Yamaguchi, T., et al. 1999. Neurosci Res. 35: 77-83. PMID: 10616911
  3. Vagal CCK and 5-HT(3) receptors are unlikely to mediate LPS or IL-1beta-induced fever.  |  Martin, SM., et al. 2000. Am J Physiol Regul Integr Comp Physiol. 279: R960-5. PMID: 10956254
  4. 5-hydroxytryptamine3 (5-HT3) receptors mediate spinal 5-HT antinociception: an antisense approach.  |  Paul, D., et al. 2001. J Pharmacol Exp Ther. 298: 674-8. PMID: 11454930
  5. Role of supraspinal serotonin receptors for micturition in normal conscious rats.  |  Ishizuka, O., et al. 2002. Neurourol Urodyn. 21: 225-30. PMID: 11948716
  6. A neurohormonal role for serotonin in the control of locust oviducts.  |  Lange, AB. 2004. Arch Insect Biochem Physiol. 56: 179-90. PMID: 15274179
  7. Characterization of serotonin receptors in isolated rat intramyocardial coronary artery.  |  Lai, FM., et al. 1991. J Pharmacol Exp Ther. 256: 164-8. PMID: 1988655
  8. LY277359 maleate: a potent and selective 5-HT3 receptor antagonist without gastroprokinetic activity.  |  Cohen, ML., et al. 1990. J Pharmacol Exp Ther. 254: 350-5. PMID: 2366187
  9. The action of 5-HT on calcium-dependent potassium channels and on the spinal locomotor network in lamprey is mediated by 5-HT1A-like receptors.  |  Wikström, M., et al. 1995. Brain Res. 678: 191-9. PMID: 7620887
  10. Serotonin receptor subtypes in spinal antinociception in the rat.  |  Xu, W., et al. 1994. J Pharmacol Exp Ther. 269: 1182-9. PMID: 8014862
  11. Motor-modifying properties of 5-HT3 and 5-HT4 receptor agonists on ovine abomasum.  |  Brikas, P. 1994. Zentralbl Veterinarmed A. 41: 150-8. PMID: 8091891
  12. Regulation of serotonin-induced DNA synthesis of bovine pulmonary artery smooth muscle cells.  |  Lee, SL., et al. 1994. Am J Physiol. 266: L53-60. PMID: 8304470
  13. Characterization of a postjunctional 5-HT receptor mediating relaxation of guinea-pig isolated ileum.  |  Carter, D., et al. 1995. Eur J Pharmacol. 280: 243-50. PMID: 8566092
  14. Role of serotoninergic receptors in gonadotropin secretion in male rats.  |  Pinilla, L., et al. 1997. J Endocrinol Invest. 20: 410-6. PMID: 9309540

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Methylserotonin maleate salt, 50 mg

sc-251787
50 mg
$576.00