Molecular structure of 2-Methyl Hippuric Acid, CAS Number: 42013-20-7
2-Methyl Hippuric Acid (CAS 42013-20-7)
Alternate Names:
2-[(2-methylphenyl)formamido]acetic acid; N-(o-Toluoyl)glycine
Application:
2-Methyl Hippuric Acid is the primary metabolite of o-xylene
CAS Number:
42013-20-7
Molecular Weight:
193.20
Molecular Formula:
C10H11NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
2-Methyl Hippuric Acid is formed when the amino acid, glycine, conjugates with benzoic acid. This conjugation process occurs in the liver and results in the formation of 2-Methyl Hippuric Acid, which is excreted in the urine. The presence of 2-Methyl Hippuric Acid in urine is indicative of exposure to certain environmental toxins and chemicals, as well as the body′s ability to metabolize and eliminate these substances. 2-Methyl Hippuric Acid has been studied as a potential biomarker for assessing environmental and occupational exposure to toluene, a solvent found in paints, thinners, and adhesives.
2-Methyl Hippuric Acid (CAS 42013-20-7) References
- Effect of chlorophenoxyacetic acid herbicides on glycine conjugation of benzoic acid. | Gregus, Z., et al. 1999. Xenobiotica. 29: 547-59. PMID: 10426554
- New approaches to the metabolism of xylenes: verification of the formation of phenylmercapturic acid metabolites of xylenes. | Gonzalez-Reche, LM., et al. 2003. Arch Toxicol. 77: 80-5. PMID: 12590359
- Complete separation of urinary metabolites of xylene in HPLC/DAD using β-cyclodextrin: application for biological monitoring. | Caporossi, L., et al. 2010. J Chromatogr B Analyt Technol Biomed Life Sci. 878: 2611-5. PMID: 20102796
- Uremic toxins inhibit transport by breast cancer resistance protein and multidrug resistance protein 4 at clinically relevant concentrations. | Mutsaers, HA., et al. 2011. PLoS One. 6: e18438. PMID: 21483698
- Urinary metabolites before and after cleanup and subjective symptoms in volunteer participants in cleanup of the Hebei Spirit oil spill. | Ha, M., et al. 2012. Sci Total Environ. 429: 167-73. PMID: 22591993
- Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration. | Mutsaers, HA., et al. 2013. Biochim Biophys Acta. 1832: 142-50. PMID: 23017367
- Procyanidin B2 protects against d-galactose-induced mimetic aging in mice: Metabolites and microbiome analysis. | Xiao, Y., et al. 2018. Food Chem Toxicol. 119: 141-149. PMID: 29751077
- Effect of Huangqin Tang on Urine Metabolic Profile in Rats with Ulcerative Colitis Based on UPLC-Q-Exactive Orbitrap MS. | Wang, D., et al. 2020. Evid Based Complement Alternat Med. 2020: 1874065. PMID: 32382278
- Based on urine metabolomics to study the mechanism of Qi-deficiency affecting type 2 diabetes rats using ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. | Gao, Y., et al. 2021. J Chromatogr B Analyt Technol Biomed Life Sci. 1179: 122850. PMID: 34364297
- Application of MIL-53(Al)-NH2 as a Dispersive Microsolid-Phase Extraction Material for Determination of Cyclophosphamide in Urine by High-Performance Liquid Chromatography. | Rahimpoor, R., et al. 2022. ACS Omega. 7: 36643-36652. PMID: 36278040
- Developmental programming: Preconceptional and gestational exposure of sheep to a real-life environmental chemical mixture alters maternal metabolome in a fetal sex-specific manner. | Thangaraj, SV., et al. 2023. Sci Total Environ. 864: 161054. PMID: 36565874
- [Determination of seven monoaromatic hydrocarbon metabolites by ultra performance liquid chromatography-tandem mass spectrometry]. | Qiu, T., et al. 2023. Se Pu. 41: 366-375. PMID: 37005924
- Effects of fibrates on the glycine conjugation of benzoic acid in rats. | Gregus, Z., et al. 1998. Drug Metab Dispos. 26: 1082-8. PMID: 9806950
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Methyl Hippuric Acid, 1 g | sc-220747 | 1 g | $121.00 |