Date published: 2026-4-4

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2-Methyl-4-isothiazolin-3-one (CAS 2682-20-4)

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Alternate Names:
N-Methyl-3-oxodihydro isothiazole; 2-Methyl-3(2H)-isothiazolone
Application:
2-Methyl-4-isothiazolin-3-one is a potent biocide useful for controlling microbial growth
CAS Number:
2682-20-4
Purity:
≥98.0%
Molecular Weight:
115.15
Molecular Formula:
C4H5NOS
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Methyl-4-isothiazolin-3-one is recognized for its role in the field of industrial and applied microbiology, where it is employed as a biocide in a range of applications. In research, it′s often used to explore the efficacy of antimicrobial agents in various environmental conditions, providing insights into the preservation of materials. Its mechanism of action, which involves the inhibition of microbial growth by interfering with certain enzymatic activities within the cell, makes it an interesting subject for studies on microbial resistance and biofilm formation. This compound is also a topic of interest in the development of novel industrial preservatives, with researchers investigating its stability and activity in a wide range of products and environments. Furthermore, 2-Methyl-4-isothiazolin-3-one′s role in the degradation of polymers offers a pathway to understand and improve the longevity and durability of materials exposed to microbial threats.


2-Methyl-4-isothiazolin-3-one (CAS 2682-20-4) References

  1. Contact sensitization to 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one in children.  |  Tosti, A., et al. 2003. Contact Dermatitis. 49: 215-6. PMID: 14996074
  2. Antifungal activities of bronopol and 2-methyl-4-isothiazolin-3-one (MT) against saprolegnia.  |  Oono, H. and Hatai, K. 2007. Biocontrol Sci. 12: 145-8. PMID: 18198720
  3. Three-phase hollow-fiber liquid-phase microextraction combined with HPLC-UV for the determination of isothiazolinone biocides in adhesives used for food packaging materials.  |  Rosero-Moreano, M., et al. 2014. J Sep Sci. 37: 272-80. PMID: 24302646
  4. Analysis of isothiazolinone preservatives in polyvinyl alcohol cooling towels used in Japan.  |  Kawakami, T., et al. 2014. J Environ Sci Health A Tox Hazard Subst Environ Eng. 49: 1209-17. PMID: 24967553
  5. In vitro activity of seven hospital biocides against Mycobacterium abscessus: Implications for patients with cystic fibrosis.  |  Caskey, S., et al. 2018. Int J Mycobacteriol. 7: 45-47. PMID: 29516885
  6. Development of a highly efficient electrochemical flow-through anode based on inner in-site enhanced TiO2-nanotubes array.  |  Chen, M., et al. 2020. Environ Int. 140: 105813. PMID: 32480113
  7. Degradation of a non-oxidizing biocide in circulating cooling water using UV/persulfate: Kinetics, pathways, and cytotoxicity.  |  Cui, J., et al. 2022. Chemosphere. 289: 133064. PMID: 34838601
  8. Functional and dynamic mitochondrial damage by chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) mixture in brain endothelial cell lines and rat cerebrovascular endothelium.  |  Kim, D., et al. 2022. Toxicol Lett. 366: 45-57. PMID: 35803525
  9. Analysis and control of fungal deterioration on the surface of pottery figurines unearthed from the tombs of the Western Han Dynasty.  |  Wang, Y., et al. 2022. Front Microbiol. 13: 956774. PMID: 36046016
  10. Contact allergy to a contaminant in Kathon CG in the guinea pig.  |  Bruze, M., et al. 1987. Derm Beruf Umwelt. 35: 165-8. PMID: 3691315
  11. Absorption and disposition of 14C-labelled Kathon biocide, a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, following intravenous or dermal administration to male Sprague-Dawley rats.  |  deBethizy, JD., et al. 1986. Food Chem Toxicol. 24: 43-9. PMID: 3949268
  12. The genetic toxicology of Kathon biocide, a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one.  |  Scribner, HE., et al. 1983. Mutat Res. 118: 129-52. PMID: 6410231
  13. Occupational dermatitis from isothiazolinones in the nylon production.  |  Valsecchi, R., et al. 1993. Dermatology. 187: 109-11. PMID: 8358097

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Methyl-4-isothiazolin-3-one, 5 g

sc-230522
5 g
$94.00

2-Methyl-4-isothiazolin-3-one, 100 g

sc-230522A
100 g
$195.00

2-Methyl-4-isothiazolin-3-one, 500 g

sc-230522B
500 g
$520.00

2-Methyl-4-isothiazolin-3-one, 1 kg

sc-230522C
1 kg
$900.00