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2-Methyl-4,6-dinitrophenol (CAS 534-52-1)

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Alternate Names:
4,6-Dinitro-o-cresol; DNOC
CAS Number:
534-52-1
Purity:
≥95%
Molecular Weight:
198.13
Molecular Formula:
C7H6N2O5
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Methyl-4,6-dinitrophenol serves as a metabolic uncoupler in experimental applications. It disrupts the process of oxidative phosphorylation in mitochondria by dissipating the proton gradient across the inner mitochondrial membrane. At the molecular level, 2-Methyl-4,6-dinitrophenol acts by allowing protons to freely re-enter the mitochondrial matrix, uncoupling the process of ATP synthesis from the electron transport chain. 2-Methyl-4,6-Dinitrophenol′s mechanism of action involves interfering with the normal flow of electrons in the respiratory chain, leading to the dissipation of energy as heat instead of the production of ATP. In experimental applications, 2-Methyl-4,6-dinitrophenol is used to study the regulation of energy metabolism and the physiological consequences of uncoupling oxidative phosphorylation.


2-Methyl-4,6-dinitrophenol (CAS 534-52-1) References

  1. Sorption and degradation of the herbicide 2-methyl-4,6-dinitrophenol under aerobic conditions in a sandy aquifer in Vejen, Denmark.  |  Broholm, MM., et al. 2001. Environ Sci Technol. 35: 4789-97. PMID: 11775154
  2. Hydrogen peroxide photolysis, fenton reagent and photo-fenton for the degradation of nitrophenols: a comparative study.  |  Goi, A. and Trapido, M. 2002. Chemosphere. 46: 913-22. PMID: 11922072
  3. [DNOC extractability from aqueous solutions].  |  Shormanov, VK. 1990. Sud Med Ekspert. 33: 35-6. PMID: 2080538
  4. Electrochemical sensing of 2-methyl-4, 6-dinitrophenol by nanomagnetic core shell linked to carbon nanotube modified glassy carbon electrode.  |  Irandoust, M., et al. 2019. Mater Sci Eng C Mater Biol Appl. 99: 211-221. PMID: 30889693
  5. Screening of organic chemicals in surface water of the North River by high resolution mass spectrometry.  |  Zhao, JH., et al. 2022. Chemosphere. 290: 133174. PMID: 34871619
  6. [Effects of plant protective agents and pesticides on the processibility of milk with special consideration to microbiological technology].  |  Konrad, H. and Gabrio, T. 1976. Nahrung. 20: 715-24. PMID: 989158

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Methyl-4,6-dinitrophenol, 250 mg

sc-238139
250 mg
$32.00

2-Methyl-4,6-dinitrophenol, 1 g

sc-238139A
1 g
$64.00

2-Methyl-4,6-dinitrophenol, 5 g

sc-238139B
5 g
$128.00

2-Methyl-4,6-dinitrophenol, 10 g

sc-238139C
10 g
$194.00