Date published: 2026-4-24

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2-Methyl-2-butenenitrile (CAS 4403-61-6)

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Alternate Names:
2-Cyano-2-butene; 1-Methyl-1-propenyl Cyanide
CAS Number:
4403-61-6
Molecular Weight:
81.12
Molecular Formula:
C5H7N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Methyl-2-butenenitrile is a transparent, colorless fluid that is slightly soluble in water but dissolves readily in organic solvents like ether and acetone. This substance is combustible and is reactive when exposed to oxidizing agents, acids, and bases. It can be used as a starting material for synthesizing diverse organic compounds, for instance, 2-methyl-2-phenylpropanenitrile, and is useful in microbiological studies for assessing the antimicrobial efficacy of different substances. When reacted with aluminum oxide, 2-Methyl-2-butenenitrile converts to an inorganic compound, facilitating the creation of ligands and produces the bond cleavage step in chemical reactions. It is recognized for its interaction with cytochrome P450 enzymes, essential for molecular metabolism.


2-Methyl-2-butenenitrile (CAS 4403-61-6) References

  1. Biosynthesis of rhodiocyanosides in Lotus japonicus: rhodiocyanoside A is synthesized from (Z)-2-methylbutanaloxime via 2-methyl-2-butenenitrile.  |  Saito, S., et al. 2012. Phytochemistry. 77: 260-7. PMID: 22385904
  2. Polyvinyl Alcohol Reinforced Flame-Retardant Polyacrylonitrile Composite Fiber Prepared by Boric Acid Cross-Linking and Phosphorylation.  |  Ren, Y., et al. 2018. Materials (Basel). 11: PMID: 30486471
  3. Influence of Conditioning Temperature on the Quality, Nutritional Properties and Volatile Profile
of Virgin Rapeseed Oil.  |  Kraljić, K., et al. 2018. Food Technol Biotechnol. 56: 562-572. PMID: 30923453
  4. Comprehensive two-dimensional gas chromatography-time of flight mass spectrometry as a tool for tracking roasting-induced changes in the volatilome of cold-pressed rapeseed oil.  |  Drabińska, N., et al. 2023. Anal Bioanal Chem. 415: 2523-2534. PMID: 36567330

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Methyl-2-butenenitrile, 25 ml

sc-230504
25 ml
$46.00

2-Methyl-2-butenenitrile, 500 ml

sc-230504A
500 ml
$255.00