Date published: 2025-10-20

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2-methoxyethanethiol (CAS 10494-75-4)

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Alternate Names:
2-methoxyethane-1-thiol
CAS Number:
10494-75-4
Molecular Weight:
92.16
Molecular Formula:
C3H8OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Methoxyethanethiol, a sulfur-containing organic compound with the chemical formula C3H8OS, emits a strong garlic-like odor. 2-Methoxyethanethiol serves as a valuable reagent in various biochemical assays, especially in the exploration of protein structure and function. Additionally, it functions as a powerful tool in studying cellular signaling pathways and the intricate mechanisms governing gene expression. 2-Methoxyethanethiol acts as a nucleophile, entering into reactions with electrophilic molecules to form covalent bonds.


2-methoxyethanethiol (CAS 10494-75-4) References

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  2. Modification of Poly(5,6-epoxy-l-norleucine) Gives Functional Polypeptides with Alternative Side-Chain Linkages.  |  Perlin, P., et al. 2020. Biomacromolecules. 21: 126-132. PMID: 31482703
  3. Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo.  |  Kaoud, TS., et al. 2019. Nat Commun. 10: 5232. PMID: 31745079
  4. Cysteine-to-lysine transfer antibody fragment conjugation.  |  Forte, N., et al. 2019. Chem Sci. 10: 10919-10924. PMID: 32190247
  5. Slow-binding inhibition of chymotrypsin and cathepsin G by the peptide aldehyde chymostatin.  |  Stein, RL. and Strimpler, AM. 1987. Biochemistry. 26: 2611-5. PMID: 3607037
  6. Thiol addition to the carbonyl group. Equilibria and kinetics.  |  Lienhard, GE. and Jencks, WP. 1966. J Am Chem Soc. 88: 3982-94. PMID: 5915153
  7. Chloroacetone as an active-site-directed inhibitor of the aliphatic amidase from Pseudomonas aeruginosa.  |  Hollaway, MR., et al. 1980. Biochem J. 191: 811-26. PMID: 6793036
  8. Cationic [99mTcIII(DIARS)2(SR)2]+ complexes as potential myocardial perfusion imaging agents (DIARS = o-phenylenebis(dimethylarsine);SR- = thiolate).  |  Tisato, F., et al. 1996. J Med Chem. 39: 1253-61. PMID: 8632432

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-methoxyethanethiol, 1 g

sc-342956
1 g
$612.00

2-methoxyethanethiol, 5 g

sc-342956A
5 g
$1796.00