Date published: 2026-4-30

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2-Methoxy-N-methylaniline (CAS 10541-78-3)

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CAS Number:
10541-78-3
Molecular Weight:
137.18
Molecular Formula:
C8H11NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Methoxy-N-methylaniline (2-MNA) is an amine compound widely employed in scientific research with a diverse range of applications. Its utilization in various studies facilitates the exploration of the biochemical, physiological, and cellular impacts of specific compounds. It has been instrumental in examining the influence of particular compounds on cell growth, differentiation, and metabolism. Furthermore, it has contributed to the investigation of compound effects on the immune, cardiovascular, and nervous systems.


2-Methoxy-N-methylaniline (CAS 10541-78-3) References

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  2. Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists.  |  Duan, H., et al. 2012. J Med Chem. 55: 10475-89. PMID: 23148522
  3. Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; application of Buchwald-Hartwig aminations of heterocycles.  |  Gangjee, A., et al. 2013. J Med Chem. 56: 4422-41. PMID: 23627352
  4. Novel N-methylsulfonamide and retro-N-methylsulfonamide derivatives as 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors with good ADME-related physicochemical parameters.  |  Perspicace, E., et al. 2013. Eur J Med Chem. 69: 201-15. PMID: 24036043
  5. A Copper-Based Metal-Organic Framework as an Efficient and Reusable Heterogeneous Catalyst for Ullmann and Goldberg Type C-N Coupling Reactions.  |  Long, W., et al. 2015. Molecules. 20: 21178-92. PMID: 26633320
  6. Sulfonamide-Based Inhibitors of Aminoglycoside Acetyltransferase Eis Abolish Resistance to Kanamycin in Mycobacterium tuberculosis.  |  Garzan, A., et al. 2016. J Med Chem. 59: 10619-10628. PMID: 27933949
  7. N-Methylation of ortho-substituted aromatic amines with methanol catalyzed by 2-arylbenzo[d]oxazole NHC-Ir(iii) complexes.  |  Huang, S., et al. 2019. Dalton Trans. 48: 5072-5082. PMID: 30920560
  8. Iron porphyrin-catalyzed N-trifluoroethylation of anilines with 2,2,2-trifluoroethylamine hydrochloride in aqueous solution.  |  Ren, S., et al. 2021. RSC Adv. 11: 20322-20325. PMID: 35479926
  9. One-pot synthesis of N-methylindoles from N-methylanilines and of benzofurans from phenols using transition-metal carbene X–H insertion reactions  |  Mark A. Honey a, Alexander J. Blake a, Ian B. Campbell b, Brian D. Judkins b, Christopher J. Moody a. 2009. Tetrahedron. 65: 8995-9001.
  10. Easily assembled, modular N,O-chelating ligands for Ta(V) complexation: a comparative study of ligand effects in hydroaminoalkylation with N-methylaniline and 4-methoxy-N-methylaniline  |  Pierre Garcia a, Philippa R. Payne a, Eugene Chong a, Ruth L. Webster a, Benedict J. Barron a, Andrew C. Behrle b, Joseph A.R. Schmidt b, Laurel L. Schafer a. 2013. Tetrahedron. 69: 5737-5743.
  11. Iodine-catalyzed cycloalkenylation of dihydroquinolines and arylamines through a reaction with cyclic ketones under neat conditions  |  Jean Fotie a, Suraj K. Ayer a, Binit S. Poudel a, Carolyn S. Reid b. 2013. Tetrahedron Letters. 54: 7069-7073.
  12. Visualizing nitric oxide-dependent HIF-1 activity under hypoxia with a lipid droplet-targeting fluorescent probe  |  Ying-Hao Pan, Xiao-Xiao Chen, Lei Dong, Na Shao, Li-Ya Niu, Qing-Zheng Yang. 2021. Chinese Chemical Letters. 32: 3895-3898.
  13. Ruthenium(ii) arene complexes bearing simple dioxime ligands: effective catalysts for the one-pot transfer hydrogenation/N-methylation of nitroarenes with methanol  |  Roberta Colaiezzi, ‡a Chiara Saviozzi, ‡bc Nicola di Nicola,a Stefano Zacchini, d Guido Pampaloni, bc Marcello Crucianelli, a Fabio Marchetti, bc Andrea Di Giuseppe *a and Lorenzo Biancalana *bc . 2023. Catal. Sci. Technol.,. 13: 2160-2183.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Methoxy-N-methylaniline, 1 g

sc-225453
1 g
$95.00