2-Mercapto-L-histidine (CAS 2002-22-4)
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2-Mercapto-L-histidine is a naturally occurring amino acid found in dietary sources, and it demonstrates notable efficacy as an inhibitor of opportunistic fungal growth under laboratory conditions. In vitro studies have revealed that it possesses a second-order rate constant of 0.0037 s−1, comparable to that of lysine and arginine. The inhibitory mechanism of this compound involves competition with tryptophan for binding sites on the enzyme histidine ammonia-lyase, effectively impeding fungal growth. Moreover, 2-Mercapto-L-histidine exhibits reactivity towards nucleophiles, including divalent cations, leading to the formation of covalent bonds. This characteristic may contribute to its antimicrobial activity against Gram-positive bacteria.
2-Mercapto-L-histidine (CAS 2002-22-4) References
- Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6. | D'Onofrio, N., et al. 2016. Free Radic Biol Med. 96: 211-22. PMID: 27101740
- Ergothioneine Antioxidant Function: From Chemistry to Cardiovascular Therapeutic Potential. | Servillo, L., et al. 2017. J Cardiovasc Pharmacol. 69: 183-191. PMID: 28375902
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Mercapto-L-histidine, 25 mg | sc-470974 | 25 mg | $296.00 |