Date published: 2026-2-12

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2-maleimidoethylamine hydrochloride (CAS 134272-64-3)

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Alternate Names:
N-(2-Aminoethyl)maleimide Hydrochloride; 1-(2-aminoethyl)-1H-pyrrole-2,5-dione hydrochloride
Application:
2-maleimidoethylamine hydrochloride is a heterobifunctional linker
CAS Number:
134272-64-3
Purity:
≥95%
Molecular Weight:
176.60
Molecular Formula:
C6H8N2O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-maleimidoethylamine hydrochloride interacts with cellular components by forming covalent bonds with thiol groups on proteins, leading to the modification of their structure and function. This modification can influence cellular processes such as protein folding, trafficking, and signaling pathways. 2-maleimidoethylamine hydrochloride′s interaction with cellular components can affect the activity of enzymes and transcription factors, leading to changes in gene expression and cellular responses to stimuli. 2-maleimidoethylamine hydrochloride can impact the redox state of the cell by reacting with thiol-containing antioxidants, potentially influencing cellular oxidative stress and signaling.


2-maleimidoethylamine hydrochloride (CAS 134272-64-3) References

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  2. Site-specific PEGylation endows a mammalian ribonuclease with antitumor activity.  |  Rutkoski, TJ., et al. 2011. Cancer Biol Ther. 12: 208-14. PMID: 21633186
  3. Large enhancement in neurite outgrowth on a cell membrane-mimicking conducting polymer.  |  Zhu, B., et al. 2014. Nat Commun. 5: 4523. PMID: 25060339
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  7. X-Ray responsive nanoparticles with triggered release of nitrite, a precursor of reactive nitrogen species, for enhanced cancer radiosensitization.  |  Liu, F., et al. 2017. Nanoscale. 9: 14627-14634. PMID: 28936509
  8. Tetrafluorination of Aromatic Azide Yields a Highly Efficient Staudinger Reaction: Kinetics and Biolabeling.  |  Xie, Y., et al. 2018. Chem Asian J.. PMID: 29714052
  9. Histidine-Mediated Intramolecular Electrostatic Repulsion for Controlling pH-Dependent Protein-Protein Interaction.  |  Watanabe, H., et al. 2019. ACS Chem Biol. 14: 2729-2736. PMID: 31596562
  10. Site-specific radioiodination of an anti-HER2 single domain antibody fragment with a residualizing prosthetic agent.  |  Feng, Y., et al. 2021. Nucl Med Biol. 92: 171-183. PMID: 32448731
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-maleimidoethylamine hydrochloride, 100 mg

sc-265752
100 mg
$92.00

2-maleimidoethylamine hydrochloride, 1 g

sc-265752A
1 g
$317.00

2-maleimidoethylamine hydrochloride, 5 g

sc-265752B
5 g
$1004.00