Date published: 2025-11-1

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2-Linoleoyl glycerol (CAS 3443-82-1)

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Alternate Names:
9Z, 12Z-octadecadienoic acid; 2- glyceryl ester; 2-LG
Application:
2-Linoleoyl glycerol is an endocannabinoid which potentiates the action of other endocannabinoids
CAS Number:
3443-82-1
Molecular Weight:
354.52
Molecular Formula:
C21H38O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Linoleoyl glycerol, with CAS number 3443-82-1, is a monoacylglycerol where linoleic acid, a polyunsaturated omega-6 fatty acid, is esterified at the second position of a glycerol backbone. This compound is an important intermediate in lipid metabolism and is involved in various cellular signaling pathways. It is produced naturally in the body through the hydrolysis of diacylglycerols by diacylglycerol lipases or through the direct acylation of glycerol. In research contexts, 2-linoleoyl glycerol is extensively utilized to study the biochemistry of lipid metabolism and the roles of fatty acids and monoacylglycerols in cellular processes. Specifically, it is used to understand the dynamics of signal transduction that involve monoacylglycerols, which are known to impact cellular mechanisms such as energy balance, lipid storage, and the modulation of membrane dynamics. Insights gained from studies using 2-linoleoyl glycerol contribute to a broader understanding of how cells utilize and regulate lipid molecules, particularly in the context of cellular responses to environmental and metabolic stimuli. By exploring the function and pathways associated with 2-linoleoyl glycerol, researchers can explain the complex interplay between different types of lipids in the complex network of cellular signaling and metabolism. This research helps to map out critical biochemical pathways that manage lipid-based signaling and energy regulation within cells.


2-Linoleoyl glycerol (CAS 3443-82-1) References

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  2. Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB1 Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in Drosophila melanogaster.  |  Tortoriello, G., et al. 2021. Cannabis Cannabinoid Res. 6: 119-136. PMID: 33912677
  3. Activation of TRPV1 by Capsaicin or Heat Drives Changes in 2-Acyl Glycerols and N-Acyl Ethanolamines in a Time, Dose, and Temperature Dependent Manner.  |  Manchanda, M., et al. 2021. Front Cell Dev Biol. 9: 611952. PMID: 33937226
  4. Endocannabinoids produced in photoreceptor cells in response to light activate Drosophila TRP channels.  |  Sokabe, T., et al. 2022. Sci Signal. 15: eabl6179. PMID: 36219683
  5. Hyperthermia-Induced Seizures Enhance Brain Concentrations of the Endocannabinoid-Related Linoleoyl Glycerols in a Scn1a+/- Mouse Model of Dravet Syndrome.  |  Bahceci, D., et al. 2023. Cannabis Cannabinoid Res. 8: 495-504. PMID: 36269656
  6. The Endocannabinoid Analgesic Entourage Effect: Investigations in Cultured DRG Neurons.  |  Anand, U., et al. 2022. J Pain Res. 15: 3493-3507. PMID: 36394060
  7. Sex Modifies the Impact of Type 2 Diabetes Mellitus on the Murine Whole Brain Metabolome.  |  Norman, JE., et al. 2023. Metabolites. 13: PMID: 37755291
  8. 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells.  |  Sugiura, T., et al. 1996. Biochem Biophys Res Commun. 229: 58-64. PMID: 8954083
  9. Is the cannabinoid CB1 receptor a 2-arachidonoylglycerol receptor? Structural requirements for triggering a Ca2+ transient in NG108-15 cells.  |  Sugiura, T., et al. 1997. J Biochem. 122: 890-5. PMID: 9399597
  10. An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity.  |  Ben-Shabat, S., et al. 1998. Eur J Pharmacol. 353: 23-31. PMID: 9721036

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Linoleoyl glycerol, 500 µg

sc-223446
500 µg
$19.00

2-Linoleoyl glycerol, 1 mg

sc-223446A
1 mg
$32.00