Date published: 2025-9-27

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2-Ketobutyric acid (CAS 600-18-0)

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Alternate Names:
alpha-Ketobutyric Acid; Propionylformic acid
Application:
2-Ketobutyric acid is A important member of amino acid metabolism
CAS Number:
600-18-0
Purity:
≥95%
Molecular Weight:
102.09
Molecular Formula:
C4H6O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Ketobutyric acid is a important member of amino acid metabolism and is involved in the metabolism of carbohydrates, proteins, and lipids. It is an important intermediate in the Krebs cycle and a key intermediate in the biosynthesis of amino acids, lipids, glucose, and other molecules. Scientific researchers use this chemical to study energy metabolism, the regulation of gene expression, and the regulation of enzyme activity.


2-Ketobutyric acid (CAS 600-18-0) References

  1. Metabolic and K(ATP) channel-independent actions of keto acid initiators of insulin secretion.  |  McClenaghan, NH. and Flatt, PR. 2000. Pancreas. 20: 38-46. PMID: 10630382
  2. Electrospray ionization mass spectrometry in the structural characterization of some diphenyllead(IV) thiosemicarbazonates.  |  Casas, JS., et al. 2004. Rapid Commun Mass Spectrom. 18: 1856-64. PMID: 15329880
  3. Identification of a sotolon pathway in dry white wines.  |  Pons, A., et al. 2010. J Agric Food Chem. 58: 7273-9. PMID: 20486709
  4. Plasma Metabolic Profiling Analysis of Gout Party on Acute Gout Arthritis Rats Based on UHPLC-Q-TOF/MS Combined with Multivariate Statistical Analysis.  |  Wang, Y., et al. 2019. Int J Mol Sci. 20: PMID: 31731809
  5. Metabolic engineering of Corynebacterium glutamicum WM001 to improve l-isoleucine production.  |  Zhang, Y., et al. 2021. Biotechnol Appl Biochem. 68: 568-584. PMID: 32474971
  6. [Synthesis of L-2-aminobutyric acid by leucine dehydrogenase coupling with an NADH regeneration system].  |  Zhang, L., et al. 2020. Sheng Wu Gong Cheng Xue Bao. 36: 992-1001. PMID: 32567282
  7. Plasma metabolomic study in perinatally HIV-infected children using 1H NMR spectroscopy reveals perturbed metabolites that sustain during therapy.  |  Kaur S, U., et al. 2020. PLoS One. 15: e0238316. PMID: 32866201
  8. Efficient single whole-cell biotransformation for L-2-aminobutyric acid production through engineering of leucine dehydrogenase combined with expression regulation.  |  Chen, J., et al. 2021. Bioresour Technol. 326: 124665. PMID: 33540211
  9. Metabolic changes from exposure to harmful Maillard reaction products and high-fat diet on Sprague-Dawley rats.  |  Quan, W., et al. 2021. Food Res Int. 141: 110129. PMID: 33641996
  10. Development of efficient microbial cell factory for whole-cell bioconversion of L-threonine to 2-hydroxybutyric acid.  |  Le, T. and Park, S. 2022. Bioresour Technol. 344: 126090. PMID: 34634464
  11. Aroylhydrazone Diorganotin Complexes Causes DNA Damage and Apoptotic Cell Death: From Chemical Synthesis to Biochemical Effects.  |  Jiang, W., et al. 2021. Int J Mol Sci. 22: PMID: 34948323
  12. Effects of Cage and Floor Rearing Systems on the Metabolic Components of the Uropygial Gland in Ducks.  |  Liu, H., et al. 2022. Animals (Basel). 12: PMID: 35049836
  13. Association Among the Gut Microbiome, the Serum Metabolomic Profile and RNA m6A Methylation in Sepsis-Associated Encephalopathy.  |  Wang, H., et al. 2022. Front Genet. 13: 859727. PMID: 35432460
  14. Exercise improves choroid plexus epithelial cells metabolism to prevent glial cell-associated neurodegeneration.  |  Chen, Y., et al. 2022. Front Pharmacol. 13: 1010785. PMID: 36188600
  15. Glucose and non-glucidic nutrients exert permissive effects on 2-keto acid regulation of pancreatic beta-cell function.  |  McClenaghan, NH. and Flatt, PR. 1999. Biochim Biophys Acta. 1426: 110-8. PMID: 9878701

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Ketobutyric acid, 5 g

sc-256168
5 g
$61.00

2-Ketobutyric acid, 10 g

sc-256168A
10 g
$87.00

2-Ketobutyric acid, 25 g

sc-256168B
25 g
$199.00