Date published: 2025-10-20

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2-Isopropylthioxanthone (CAS 5495-84-1)

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CAS Number:
5495-84-1
Molecular Weight:
254.35
Molecular Formula:
C16H14OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Isopropylthioxanthone (2-IPX) is a member of the thioxanthone family. It takes the form of yellow crystalline solid, soluble in organic solvents like ethanol and benzene, and boasts a range of industrial and scientific applications. In the realm of scientific research, 2-Isopropylthioxanthone is incredibly versatile. It plays a role as a fluorescent dye in analytical chemistry, aiding in the detection and measurement of various substances. Additionally, it serves as a photochemical agent in the field of photochemistry, allowing for light-induced reactions and the subsequent formation of desired products. Moreover, 2-Isopropylthioxanthone finds utility as a reagent in organic synthesis, enabling the creation of intricate molecular structures. Furthermore, this compound proves valuable in the study of enzyme kinetics and acts as a marker for detecting protein-protein interactions. The photochemical nature of 2-Isopropylthioxanthone manifests through its activation by light. When exposed to light, the molecules undergo excitation and transition to an excited state, initiating a reaction. In this excited state, the molecules interact with other molecules present in the surrounding environment, leading to the formation of the desired product. The absorption of light acts as the trigger, setting in motion a series of reactions that ultimately yield the desired outcome.


2-Isopropylthioxanthone (CAS 5495-84-1) References

  1. Determination of isopropyl-9H-thioxanthen-9-one in packaged beverages by solid-phase extraction clean-up and liquid chromatography with tandem mass spectrometry detection.  |  Sun, C., et al. 2007. J Chromatogr A. 1143: 162-7. PMID: 17229432
  2. 2-Isopropylthioxanthone (2-ITX) in food and food packaging materials on the German market.  |  Rothenbacher, T., et al. 2007. Food Addit Contam. 24: 438-44. PMID: 17454118
  3. Determination of ink photoinitiators in packaged beverages by gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry.  |  Sagratini, G., et al. 2008. J Chromatogr A. 1194: 213-20. PMID: 18486139
  4. AhR-agonistic, anti-androgenic, and anti-estrogenic potencies of 2-isopropylthioxanthone (ITX) as determined by in vitro bioassays and gene expression profiling.  |  Peijnenburg, A., et al. 2010. Toxicol In Vitro. 24: 1619-28. PMID: 20558275
  5. Endocrine-disrupting effects of thioxanthone photoinitiators.  |  Reitsma, M., et al. 2013. Toxicol Sci. 132: 64-74. PMID: 23208609
  6. Photoinitiator-Initiated Estrogenic Activity in Human Breast Cancer Cell Line MCF-7.  |  Morizane, M., et al. 2015. J Toxicol Environ Health A. 78: 1450-60. PMID: 26692070
  7. Synthesis of isotopically labelled 2-isopropylthioxanthone from 2,2'-dithiosalicylic acid and deuterium cumene.  |  Fang, C., et al. 2016. J Labelled Comp Radiopharm. 59: 313-6. PMID: 27123759
  8. In silico prediction and in vivo analysis of antiestrogenic potential of 2-isopropylthioxanthone (2-ITX) in juvenile goldfish (Carassius auratus).  |  Cocci, P., et al. 2016. Ecotoxicol Environ Saf. 133: 202-10. PMID: 27454205
  9. In Situ Generated Ruthenium-Arene Catalyst for Photoactivated Ring-Opening Metathesis Polymerization through Photolatent N-Heterocyclic Carbene Ligand.  |  Pinaud, J., et al. 2018. Chemistry. 24: 337-341. PMID: 29168909
  10. Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization.  |  Pinaud, J., et al. 2018. J Vis Exp.. PMID: 30582579
  11. Mixture of Azolium Tetraphenylborate with Isopropylthioxanthone: A New Class of N-Heterocyclic Carbene (NHC) Photogenerator for Polyurethane, Polyester, and ROMP Polymers Synthesis.  |  Trinh, TKH., et al. 2019. Chemistry. 25: 9242-9252. PMID: 31021454
  12. Novel Photoinitiators Based on Benzophenone-Triphenylamine Hybrid Structure for LED Photopolymerization.  |  Liu, S., et al. 2020. Macromol Rapid Commun. 41: e2000460. PMID: 32959447
  13. Advancing 3D-Printed Microfluidics: Characterization of a Gas-Permeable, High-Resolution PDMS Resin for Stereolithography.  |  Fleck, E., et al. 2021. Micromachines (Basel). 12: PMID: 34683317
  14. A Triplet Label Extends Two-Dimensional Infrared Spectroscopy from Pico- to Microseconds.  |  Brunst, H., et al. 2022. Angew Chem Int Ed Engl. 61: e202211490. PMID: 36128955

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Isopropylthioxanthone, 5 g

sc-230447
5 g
$140.00