Molecular structure of 2-Isopropylmalic acid, CAS Number: 3237-44-3
2-Isopropylmalic acid (CAS 3237-44-3)
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Alternate Names:
2-Hydroxy-2-isopropylsuccinic acid
Application:
2-Isopropylmalic acid is an isopropyl substituted malic acid
CAS Number:
3237-44-3
Purity:
≥98%
Molecular Weight:
176.17
Molecular Formula:
C7H12O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2-Isopropylmalic acid is primarily utilized in biochemical and enzymatic studies, particularly in the context of metabolic pathway analysis. This compound helps researchers understand the intricacies of the Krebs cycle and other related metabolic processes. Its role in the metabolism of amino acids and its involvement in the synthesis of other organic acids are key areas of investigation. 2-Isopropylmalic acid is also used in studies focusing on enzyme kinetics, where it acts as a substrate for enzymes that catalyze reactions in metabolic pathways. These research efforts contribute to a broader understanding of cellular energy production and resource allocation, which are vital for the advancement of metabolic engineering and biotechnology.
2-Isopropylmalic acid (CAS 3237-44-3) References
- 2-Isopropylmalate and 3-isopropylmalate as intermediates in leucine biosynthesis. | CALVO, JM., et al. 1962. Biochemistry. 1: 1157-61. PMID: 14017963
- Secretion of an aluminum chelator, 2-isopropylmalic acid, by the budding yeast, Saccharomyces cerevisiae. | Kobayashi, A., et al. 2005. J Inorg Biochem. 99: 1260-3. PMID: 15833351
- Reduction of aluminum toxicity by 2-isopropylmalic acid in the budding yeast Saccharomyces cerevisiae. | Suzuki, T., et al. 2007. Biol Trace Elem Res. 120: 257-63. PMID: 17916978
- Extensive metabolic cross-talk in melon fruit revealed by spatial and developmental combinatorial metabolomics. | Moing, A., et al. 2011. New Phytol. 190: 683-96. PMID: 21275993
- Oxidative stress is a consequence, not a cause, of aluminum toxicity in the forage legume Lotus corniculatus. | Navascués, J., et al. 2012. New Phytol. 193: 625-636. PMID: 22136521
- Highly sensitive and selective detection of Al(III) ions in aqueous buffered solution with fluorescent peptide-based sensor. | In, B., et al. 2016. Bioorg Med Chem Lett. 26: 4477-4482. PMID: 27503680
- Identifying biomarkers for asthma diagnosis using targeted metabolomics approaches. | Checkley, W., et al. 2016. Respir Med. 121: 59-66. PMID: 27888993
- Chiral separation of disease biomarkers with 2-hydroxycarboxylic acid structure. | Calderón, C., et al. 2018. J Sep Sci. 41: 1224-1231. PMID: 29205897
- Identification and quantification of new isomers of isopropyl-malic acid in wine by LC-IT and LC-Q-Orbitrap. | Ricciutelli, M., et al. 2019. Food Chem. 294: 390-396. PMID: 31126479
- Quantification of 2- and 3-isopropylmalic acids in forty Italian wines by UHPLC-MS/MS triple quadrupole and evaluation of their antimicrobial, antioxidant activities and biocompatibility. | Ricciutelli, M., et al. 2020. Food Chem. 321: 126726. PMID: 32259735
- Determination of coeluted isomers in wine samples by application of MS/MS deconvolution analysis. | Menicatti, M., et al. 2020. J Mass Spectrom. 55: e4607. PMID: 32677749
- 2-IPMA Ameliorates PM2.5-Induced Inflammation by Promoting Primary Ciliogenesis in RPE Cells. | Choi, JY., et al. 2021. Molecules. 26: PMID: 34500843
- Primary Ciliogenesis by 2-Isopropylmalic Acid Prevents PM2.5-Induced Inflammatory Response and MMP-1 Activation in Human Dermal Fibroblasts and a 3-D-Skin Model. | Bae, JE., et al. 2021. Int J Mol Sci. 22: PMID: 34681602
- Taxonomic and Metagenomic Analyses Define the Development of the Microbiota in the Chick. | Bogomolnaya, L., et al. 2023. mBio. 14: e0244422. PMID: 36475774
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Isopropylmalic acid, 100 mg | sc-230444 | 100 mg | $117.00 |