Molecular structure of (2-Hydroxypropyl)-γ-cyclodextrin, CAS Number: 128446-34-4
(2-Hydroxypropyl)-γ-cyclodextrin (CAS 128446-34-4)
Alternate Names:
(2-Hydroxypropyl)-γ-cyclodextrin aslo known as HGC; 6A,6B,6C,6D,6E,6F,6G,6H-Octakis(2-hydroxypropyl)-gamma-cyclodextrin; Hydroxypropyl gamma-cyclodextrin gamma-Cyclodextrin; 6A,6B,6C,6D,6E,6F,6G,6H-octakis(2-hydroxypropyl)
Application:
(2-Hydroxypropyl)-γ-cyclodextrin is a gamma cyclodextrin that is a derivative of an 8-membered sugar ring molecule
CAS Number:
128446-34-4
Molecular Weight:
~1580 (avg.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
(2-Hydroxypropyl)-γ-cyclodextrin is a gamma cyclodextrin that is a derivative of an 8-membered sugar ring molecule. (2-Hydroxypropyl)-γ-cyclodextrin can crosslink to form longer polymers. This overall is a very useful chemical for supramolecular chemistry. (2-Hydroxypropyl)-γ-cyclodextrin is also used in the solubilization of macromolecules and in cell culture applications. (2-Hydroxypropyl)-γ-cyclodextrin is similar to β-Cyclodextrin (sc-204430), but (2-Hydroxypropyl)-γ-cyclodextrin can work with larger molecules.
(2-Hydroxypropyl)-γ-cyclodextrin (CAS 128446-34-4) References
- Complexation of zolpidem with 2-hydroxypropyl-beta-, methyl-beta-, and 2-hydroxypropyl-gamma-cyclodextrin: effect on aqueous solubility, dissolution rate, and ataxic activity in rat. | Trapani, G., et al. 2000. J Pharm Sci. 89: 1443-51. PMID: 11015689
- High-performance liquid chromatographic determination of 2-hydroxypropyl-gamma-cyclodextrin in different biological fluids based on cyclodextrin enhanced fluorescence. | Szemán, J., et al. 2002. J Chromatogr B Analyt Technol Biomed Life Sci. 774: 157-64. PMID: 12076685
- Two novel non-viral gene delivery vectors: low molecular weight polyethylenimine cross-linked by (2-hydroxypropyl)-beta-cyclodextrin or (2-hydroxypropyl)-gamma-cyclodextrin. | Huang, H., et al. 2006. Chem Commun (Camb). 2382-4. PMID: 16733587
- Excited-state proton transfer from pyranine to acetate in gamma-cyclodextrin and hydroxypropyl gamma-cyclodextrin. | Mondal, SK., et al. 2006. J Phys Chem A. 110: 13646-52. PMID: 17181316
- Low molecular weight polyethylenimine cross-linked by 2-hydroxypropyl-gamma-cyclodextrin coupled to peptide targeting HER2 as a gene delivery vector. | Huang, H., et al. 2010. Biomaterials. 31: 1830-8. PMID: 19942284
- Physicochemical study and characterization of the trimethoprim/2-hydroxypropyl-γ-cyclodextrin inclusion complex. | Macedo, OF., et al. 2012. Spectrochim Acta A Mol Biomol Spectrosc. 86: 101-6. PMID: 22057300
- Enhancement of curcumin wound healing ability by complexation with 2-hydroxypropyl-γ-cyclodextrin in sacran hydrogel film. | Wathoni, N., et al. 2017. Int J Biol Macromol. 98: 268-276. PMID: 28161536
- Thermodynamic parameters for the complexation of water-insoluble betulin derivatives with (2-hydroxypropyl)-γ-cyclodextrin determined by phase-solubility technique combined with capillary zone electrophoresis. | Sursyakova, VV., et al. 2019. Electrophoresis. 40: 1656-1661. PMID: 30957904
- Strong complexation of water-soluble betulin derivatives with (2-hydroxypropyl)-γ-cyclodextrin studied by affinity capillary electrophoresis. | Sursyakova, VV., et al. 2020. Electrophoresis. 41: 112-115. PMID: 31670400
- Differential Effects of 2-Hydroxypropyl-Cyclodextrins on Lipid Accumulation in Npc1-Null Cells. | Hoque, S., et al. 2020. Int J Mol Sci. 21: PMID: 32019132
- 2-Hydroxypropyl-gamma-cyclodextrin overcomes NPC1 deficiency by enhancing lysosome-ER association and autophagy. | Singhal, A., et al. 2020. Sci Rep. 10: 8663. PMID: 32457374
- Determination of binding constants for strong complexation by affinity capillary electrophoresis: the example of complexes of ester betulin derivatives with (2-hydroxypropyl)-γ-cyclodextrin. | Sursyakova, VV., et al. 2020. Anal Bioanal Chem. 412: 5615-5625. PMID: 32617760
- Boundary values of binding constants determined by affinity capillary electrophoresis. | Sursyakova, VV. and Rubaylo, AI. 2021. J Sep Sci. 44: 4200-4203. PMID: 34510741
- Encapsulation of closo-dodecaiodododecaborate in 2-hydroxypropyl-γ-cyclodextrin prevents hemolysis. | Hollow, SE. and Johnstone, TC. 2022. Chem Commun (Camb). 58: 2375-2378. PMID: 35080538
- Determination of 2-hydroxypropyl-gamma-cyclodextrin in plasma of cynomolgus monkeys after oral administration by gas chromatography-mass spectrometry. | Blum, W., et al. 1998. J Chromatogr B Biomed Sci Appl. 720: 171-8. PMID: 9892079
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(2-Hydroxypropyl)-γ-cyclodextrin, 5 g | sc-238090 | 5 g | $88.00 | |||
(2-Hydroxypropyl)-γ-cyclodextrin, 25 g | sc-238090A | 25 g | $186.00 | |||
(2-Hydroxypropyl)-γ-cyclodextrin, 100 g | sc-238090B | 100 g | $883.00 | |||
(2-Hydroxypropyl)-γ-cyclodextrin, 500 g | sc-238090C | 500 g | $2447.00 | |||
(2-Hydroxypropyl)-γ-cyclodextrin, 1 kg | sc-238090D | 1 kg | $4890.00 | |||
(2-Hydroxypropyl)-γ-cyclodextrin, 2.5 kg | sc-238090E | 2.5 kg | $11965.00 |