Molecular structure of (2-Hydroxypropyl)-β-cyclodextrin solution
(2-Hydroxypropyl)-β-cyclodextrin solution
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Alternate Names:
(2-Hydroxypropyl)-β-cyclodextrin solution is also known as HBC.
Application:
(2-Hydroxypropyl)-β-cyclodextrin solution is a chemical used for drug-delivery studies, by increasing the solubility of lipophilic drugs.
Molecular Weight:
~1396 Da
Molecular Formula:
7(C6H9O5)•4.5(C3H7O)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(2-Hydroxypropyl)-β-cyclodextrin solution is a cyclic oligosaccharide that contains seven D-(+)-glucopyranose units. (2-Hydroxypropyl)-β-cyclodextrin is used for drug-delivery studies. (2-Hydroxypropyl)-β-cyclodextrin solution increases the solubility of lipophilic drugs by forming a complex between the drug and the non-polar cavity of (2-Hydroxypropyl)-β-cyclodextrin solution. For this application, (2-Hydroxypropyl)-β-cyclodextrin solution excels with compounds containing a phenyl group. (2-Hydroxypropyl)-β-cyclodextrin solution interacts in a solution with other compounds, isolating the aromatic portion of the molecule from the water, increasing its aqueous solubility as a result.
(2-Hydroxypropyl)-β-cyclodextrin solution References
- Characterization of the interaction of 2-hydroxypropyl-beta-cyclodextrin with itraconazole at pH 2, 4, and 7. | Peeters, J., et al. 2002. J Pharm Sci. 91: 1414-22. PMID: 12115841
- A rapid screening tool for estimating the potential of 2-hydroxypropyl-beta-cyclodextrin complexation for solubilization purposes. | Trapani, A., et al. 2005. Int J Pharm. 295: 163-75. PMID: 15848001
- Co-solubilization of poorly soluble drugs by micellization and complexation. | Rao, VM., et al. 2006. Int J Pharm. 319: 98-106. PMID: 16765542
- Structural behaviour of 2-hydroxypropyl-beta-cyclodextrin in water: molecular dynamics simulation studies. | Yong, CW., et al. 2008. Pharm Res. 25: 1092-9. PMID: 18161014
- Comparative interaction of 2-hydroxypropyl-beta-cyclodextrin and sulfobutylether-beta-cyclodextrin with itraconazole: phase-solubility behavior and stabilization of supersaturated drug solutions. | Brewster, ME., et al. 2008. Eur J Pharm Sci. 34: 94-103. PMID: 18420390
- Effect of hydroxylpropyl-beta-cyclodextrin on Solubility of Carvedilol. | Shewale, BD., et al. 2008. Indian J Pharm Sci. 70: 255-7. PMID: 20046727
- The effects of cyclodextrins on the disposition of intravenously injected drugs in the rat. | Frijlink, HW., et al. 1991. Pharm Res. 8: 380-4. PMID: 2052529
- Effect of 2-hydroxypropyl-β-cyclodextrin on solubility of sparingly soluble drug derivatives of anthranilic acid. | Domańska, U., et al. 2011. Int J Mol Sci. 12: 2383-94. PMID: 21731447
- Rapid quantification of 2-hydroxypropyl-β-cyclodextrin in liquid pharmaceutical formulations by (1)H nuclear magnetic resonance spectroscopy. | Dufour, G., et al. 2015. Eur J Pharm Sci. 73: 20-8. PMID: 25797290
- Preparation, characterization and antimicrobial activity of inclusion complex of biochanin A with (2-hydroxypropyl)-β-cyclodextrin. | Nikolic, IL., et al. 2018. J Pharm Pharmacol. 70: 1485-1493. PMID: 30168133
- 2-Hydroxypropyl-β-Cyclodextrin Aggregates: Identification and Development of Analytical Techniques. | Sá Couto, AR., et al. 2018. Materials (Basel). 11: PMID: 30322145
- Ultrasound processed cuminaldehyde/2-hydroxypropyl-β-cyclodextrin inclusion complex: Preparation, characterization and antibacterial activity. | Cui, H., et al. 2019. Ultrason Sonochem. 56: 84-93. PMID: 31101292
- Effects of β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin Inclusions on the Degradation of Magnolol by Intestinal Bacteria. | Tang, L., et al. 2019. AAPS PharmSciTech. 20: 244. PMID: 31286296
- In Vivo Investigation of (2-Hydroxypropyl)-β-cyclodextrin-Based Formulation of Spironolactone in Aqueous Solution for Paediatric Use. | Lopalco, A., et al. 2022. Pharmaceutics. 14: PMID: 35456614
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(2-Hydroxypropyl)-β-cyclodextrin solution, 10 ml | sc-288158 | 10 ml | $217.00 |