2-Hydroxyglutaric Acid Disodium Salt (CAS 40951-21-1)
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2-Hydroxyglutaric Acid Disodium Salt is a compound that functions as an inhibitor of α-ketoglutarate-dependent dioxygenases. It acts by competitively inhibiting the binding of α-ketoglutarate to the active site of these enzymes, thereby disrupting their catalytic activity. This disruption leads to alterations in various cellular processes, including histone and DNA demethylation, as well as collagen and fatty acid metabolism. By interfering with these processes, 2-Hydroxyglutaric Acid Disodium Salt can be used to study the impact of α-ketoglutarate-dependent dioxygenase inhibition on cellular function and metabolism. Its mechanism of action involves directly binding to the active site of these enzymes, preventing the normal substrate from binding and undergoing catalysis. 2-Hydroxyglutaric Acid Disodium Salt ′s ability to interfere with specific cellular processes may be useful for investigating the molecular mechanisms underlying various biological pathways.
2-Hydroxyglutaric Acid Disodium Salt (CAS 40951-21-1) References
- Absolute quantification of 2-hydroxyglutarate on tissue by matrix-assisted laser desorption/ionization mass spectrometry imaging for rapid and precise identification of isocitrate dehydrogenase mutations in human glioma. | Lan, C., et al. 2021. Int J Cancer. 149: 2091-2098. PMID: 34224582
- The reversal of the myosin and actomyosin ATPase reactions and the free energy of ATP binding to myosin. | Wolcott, RG. and Boyer, PD. 1974. Biochem Biophys Res Commun. 57: 709-16. PMID: 4275131
- A catalytic mechanism for benzylamine oxidase from pig plasma. Stopped-flow kinetic studies. | Yadav, KD. and Knowles, PF. 1981. Eur J Biochem. 114: 139-44. PMID: 6260490
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Hydroxyglutaric Acid Disodium Salt, 25 mg | sc-206458 | 25 mg | $284.00 |