Molecular structure of 2-Hydroxy-flutamide, CAS Number: 52806-53-8
2-Hydroxy-flutamide (CAS 52806-53-8)
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Alternate Names:
2-Hydroxyflutamide; Hydroxyniphtholide; Sch 16423
Application:
2-Hydroxy-flutamide is an inhibitor of proliferation of estradiol-induced growth of MCF-7 breast cancer cells
CAS Number:
52806-53-8
Purity:
≥98%
Molecular Weight:
292.21
Molecular Formula:
C11H11F3N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2-Hydroxy-flutamide is a metabolite of flutamide found to inhibit the proliferation of estradiol-induced growth of MCF-7 breast cancer cells. 2-Hydroxy-flutamide is an inhibitor of AR. 2-Hydroxyflutamide, a potent androgen receptor antagonist, exhibits an IC50 value of 15 nM. As a metabolite of flutamide, it possesses antiproliferative properties but mitigates the induction of granulosa cell apoptosis when high testosterone levels are present. 2-Hydroxyflutamide is the primary metabolite resulting from the metabolism of flutamide, a non-steroidal antiandrogen, by cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4.
2-Hydroxy-flutamide (CAS 52806-53-8) References
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- Incorporation of a metabolizing system in biodetection assays for endocrine active substances. | Mollergues, J., et al. 2017. ALTEX. 34: 389-398. PMID: 28009930
- Flutamide-induced hepatotoxicity: ethical and scientific issues. | Giorgetti, R., et al. 2017. Eur Rev Med Pharmacol Sci. 21: 69-77. PMID: 28379593
- The pharmacokinetics of flutamide and its major metabolites after a single oral dose and during chronic treatment. | Schulz, M., et al. 1988. Eur J Clin Pharmacol. 34: 633-6. PMID: 3169114
- Androgen Maintains Intestinal Homeostasis by Inhibiting BMP Signaling via Intestinal Stromal Cells. | Yu, X., et al. 2020. Stem Cell Reports. 15: 912-925. PMID: 32916121
- Intracellular distribution of vinclozolin and its metabolites differently affects 5α-dihydrotestosterone (DHT)-induced PSA secretion in LNCaP cells. | Marcoccia, D., et al. 2022. Reprod Toxicol. 111: 83-91. PMID: 35595151
- Inhibitory effect of hydroxyflutamide plus tamoxifen on oestradiol-induced growth of MCF-7 breast cancer cells. | Di Monaco, M., et al. 1995. J Cancer Res Clin Oncol. 121: 710-4. PMID: 7499441
- Metabolic activation of the nitroaromatic antiandrogen flutamide by rat and human cytochromes P-450, including forms belonging to the 3A and 1A subfamilies. | Berson, A., et al. 1993. J Pharmacol Exp Ther. 265: 366-72. PMID: 8386241
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Inhibitor of:
AR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Hydroxy-flutamide, 10 mg | sc-205574 | 10 mg | $140.00 | |||
2-Hydroxy-flutamide, 25 mg | sc-205574A | 25 mg | $368.00 |