2-Hydroxy Atorvastatin Lactone (CAS 163217-74-1)
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2-Hydroxy Atorvastatin Lactone is a metabolite of atorvastatin, a widely studied statin, and is of interest in the field of biochemical research. The focus on this compound is often centered on its role in the metabolism and biotransformation of statins within the body. As a lactone form, it provides key insights into the enzymatic processes that convert statins into their active and inactive metabolites, which is for understanding their mechanisms. Researchers employ 2-Hydroxy Atorvastatin Lactone to study the activity of hepatic enzymes, such as cytochrome P450s, which are involved in the oxidation of certain chemicals. This knowledge helps in predicting chemical interactions and in optimizing dosing by understanding how different compounds are metabolized. Additionally, the compound is used in studies related to lipid metabolism, as it allows for the observation of the downstream effects of statin metabolites on cholesterol biosynthesis pathways.
2-Hydroxy Atorvastatin Lactone (CAS 163217-74-1) References
- Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin. | Jacobsen, W., et al. 2000. Drug Metab Dispos. 28: 1369-78. PMID: 11038166
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Hydroxy Atorvastatin Lactone, 1 mg | sc-213817 | 1 mg | $500.00 | |||
2-Hydroxy Atorvastatin Lactone, 1 mg | sc-213817-CW | 1 mg | $625.00 |