2-Hydroxy Atorvastatin Calcium Salt (CAS 265989-46-6)
Alternate Names:
(βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-4-[[(2-hydroxyphenyl)amino]carbonyl]-5-(1-methylethyl)-3-phenyl-1H-pyrrole-1-heptanoic Acid Calcium Salt (2:1)
Application:
2-Hydroxy Atorvastatin Calcium Salt is a metabolite of Atorvastatin Calcium Salt
CAS Number:
265989-46-6
Molecular Weight:
1187.35
Molecular Formula:
C66H68F2N4O12•Ca
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2-Hydroxy Atorvastatin Calcium Salt is an active metabolite of the selective, competitive HMG-CoA reductase inhibitor Atorvastatin. It inhibits lipid hydroperoxide formation and copper sulfate-induced thiobarbituric acid reactive substances (TBARS) formation in 1,2-dilinoleoyl-sn-glycero-3-PC (DLPC) vesicles and human LDL, respectively, in a concentration-dependent manner. 2-Hydroxy Atorvastatin reduces cell death induced by oxygen-glucose deprivation (OGD) in primary rat cortical neurons and increases phosphorylation of cAMP-response-element-binding protein (CREB) in GABAergic neurons when used at a concentration of 600 nM following OGD.
2-Hydroxy Atorvastatin Calcium Salt (CAS 265989-46-6) References
- The interconversion kinetics, equilibrium, and solubilities of the lactone and hydroxyacid forms of the HMG-CoA reductase inhibitor, CI-981. | Kearney, AS., et al. 1993. Pharm Res. 10: 1461-5. PMID: 8272408
Inhibitor of:
HMGCR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Hydroxy Atorvastatin Calcium Salt, 1 mg | sc-490441 | 1 mg | $268.00 | |||
2-Hydroxy Atorvastatin Calcium Salt, 5 mg | sc-490441A | 5 mg | $892.00 | |||
2-Hydroxy Atorvastatin Calcium Salt, 10 mg | sc-490441B | 10 mg | $1775.00 | |||
2-Hydroxy Atorvastatin Calcium Salt, 25 mg | sc-490441C | 25 mg | $3658.00 | |||
2-Hydroxy Atorvastatin Calcium Salt, 50 mg | sc-490441D | 50 mg | $5100.00 |