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2-Hydroxy-4-methoxybenzophenone (CAS 131-57-7)

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Alternate Names:
Oxybenzone
CAS Number:
131-57-7
Molecular Weight:
228.24
Molecular Formula:
C14H12O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Hydroxy-4-methoxybenzophenone is a synthetic organic compound with diverse applications, including its use in the production of plastics, dyes, and adhesives. This compound has been identified as a potential endocrine disruptor, which means it can interfere with the normal functioning of the endocrine system. The mechanism of action involves its binding to hormone receptors, thereby disrupting the normal hormone signaling pathways. Additionally, studies have revealed its interference with the reproductive system by affecting the production of hormones such as estrogen and testosterone.


2-Hydroxy-4-methoxybenzophenone (CAS 131-57-7) References

  1. Metabolism of 2-hydroxy-4-methoxybenzophenone in isolated rat hepatocytes and xenoestrogenic effects of its metabolites on MCF-7 human breast cancer cells.  |  Nakagawa, Y. and Suzuki, T. 2002. Chem Biol Interact. 139: 115-28. PMID: 11823001
  2. NTP technical report on the toxicity studies of 2-Hydroxy-4-methoxybenzophenone (CAS No. 131-57-7) Adminstered Topically and in Dosed Feed to F344/N Rats and B6C3F1 Mice.  |  French, JE. 1992. Toxic Rep Ser. 21: 1-E14. PMID: 12209185
  3. Gas chromatographic determination of 2-hydroxy-4-methoxybenzophenone and octyldimethyl-p-aminobenzoic acid sunscreen agents in swimming pool and bathing waters by solid-phase microextraction.  |  Lambropoulou, DA., et al. 2002. J Chromatogr A. 967: 243-53. PMID: 12685571
  4. Quantification of urinary conjugates of bisphenol A, 2,5-dichlorophenol, and 2-hydroxy-4-methoxybenzophenone in humans by online solid phase extraction-high performance liquid chromatography-tandem mass spectrometry.  |  Ye, X., et al. 2005. Anal Bioanal Chem. 383: 638-44. PMID: 16132150
  5. Solid-phase extraction liquid chromatography-tandem mass spectrometry analytical method for the determination of 2-hydroxy-4-methoxybenzophenone and its metabolites in both human urine and semen.  |  León, Z., et al. 2010. Anal Bioanal Chem. 398: 831-43. PMID: 20625888
  6. Growth and characterization of 2-hydroxy-4-methoxybenzophenone single crystal using modified vertical Bridgman technique.  |  Suthan, T., et al. 2011. Spectrochim Acta A Mol Biomol Spectrosc. 78: 771-6. PMID: 21216185
  7. Phototransformation of the sunlight filter benzophenone-3 (2-hydroxy-4-methoxybenzophenone) under conditions relevant to surface waters.  |  Vione, D., et al. 2013. Sci Total Environ. 463-464: 243-51. PMID: 23810862
  8. Photochemical processes involving the UV absorber benzophenone-4 (2-hydroxy-4-methoxybenzophenone-5-sulphonic acid) in aqueous solution: reaction pathways and implications for surface waters.  |  De Laurentiis, E., et al. 2013. Water Res. 47: 5943-53. PMID: 23953089
  9. Molecular structure, NBO analysis, electronic absorption and vibrational spectral analysis of 2-Hydroxy-4-Methoxybenzophenone: reassignment of fundamental modes.  |  Joseph, L., et al. 2014. Spectrochim Acta A Mol Biomol Spectrosc. 120: 216-27. PMID: 24184624
  10. Induction of chromosomal aberrations and micronuclei by 2-hydroxy-4-methoxybenzophenone (oxybenzone) in human lymphocytes.  |  Santovito, A., et al. 2019. Drug Chem Toxicol. 42: 378-385. PMID: 29648481
  11. Disposition of 2-hydroxy-4-methoxybenzophenone in rats dosed orally, intravenously, or topically.  |  el Dareer, SM., et al. 1986. J Toxicol Environ Health. 19: 491-502. PMID: 3783768
  12. Assessment of the in vivo genotoxicity of 2-hydroxy 4-methoxybenzophenone.  |  Robison, SH., et al. 1994. Environ Mol Mutagen. 23: 312-7. PMID: 8013479
  13. Assessment of the reproductive toxic potential of dermally applied 2-hydroxy-4-methoxybenzophenone to male B6C3F1 mice.  |  Daston, GP., et al. 1993. Fundam Appl Toxicol. 20: 120-4. PMID: 8432422

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Hydroxy-4-methoxybenzophenone, 5 g

sc-238071
5 g
$23.00

2-Hydroxy-4-methoxybenzophenone, 100 g

sc-238071A
100 g
$38.00