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2-hydroxy-3-methylpentanoic acid (CAS 86540-81-0)

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Alternate Names:
2-Hydroxy-3-methylvaleric acid
Application:
2-hydroxy-3-methylpentanoic acid is a derivative of L-isoleucine metabolism
CAS Number:
86540-81-0
Purity:
≥95%
Molecular Weight:
132.16
Molecular Formula:
C6H12O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-hydroxy-3-methylpentanoic acid is a derivative of L-isoleucine metabolism. It is a racemic mixture. 2-hydroxy-3-methylpentanoic acid plays a role in the regulation of fatty acid oxidation. Its main mechanism of action involves the inhibition of two key enzymes: carnitine palmitoyltransferase I, responsible for the transport of fatty acids into the mitochondria for oxidation, and acyl-CoA oxidase, involved in the oxidation process of fatty acids. By inhibiting these enzymes, 2-hydroxy-3-methylpentanoic acid modulates fatty acid metabolism.


2-hydroxy-3-methylpentanoic acid (CAS 86540-81-0) References

  1. Synthesis and gas chromatography/mass spectrometry analysis of stereoisomers of 2-hydroxy-3-methylpentanoic acid.  |  Mamer, OA. 2000. Methods Enzymol. 324: 3-10. PMID: 10989412
  2. Configurational analysis of chiral acids as O-trifluoroacetylated (-)-menthyl esters by achiral dual-capillary column gas chromatography.  |  Ki, KR., et al. 2000. J Chromatogr A. 891: 257-66. PMID: 11043786
  3. Lacticin 3147 favours isoleucine transamination by Lactococcus lactis IFPL359 in a cheese-model system.  |  Martínez-Cuesta, C., et al. 2003. Biotechnol Lett. 25: 599-602. PMID: 12882151
  4. On the mechanisms of the formation of L-alloisoleucine and the 2-hydroxy-3-methylvaleric acid stereoisomers from L-isoleucine in maple syrup urine disease patients and in normal humans.  |  Mamer, OA. and Reimer, ML. 1992. J Biol Chem. 267: 22141-7. PMID: 1429566
  5. The Bogorol family of antibiotics: template-based structure elucidation and a new approach to positioning enantiomeric pairs of amino acids.  |  Barsby, T., et al. 2006. J Org Chem. 71: 6031-7. PMID: 16872185
  6. Absolute configuration of the creatonotines and callimorphines, two classes of arctiid-specific pyrrolizidine alkaloids.  |  Beuerle, T., et al. 2007. Insect Biochem Mol Biol. 37: 80-9. PMID: 17175448
  7. Cloning and molecular characterization of the gene encoding the Aureobasidin A biosynthesis complex in Aureobasidium pullulans BP-1938.  |  Slightom, JL., et al. 2009. Gene. 431: 67-79. PMID: 19084058
  8. The Arabidopsis glucosyltransferase UGT76B1 conjugates isoleucic acid and modulates plant defense and senescence.  |  von Saint Paul, V., et al. 2011. Plant Cell. 23: 4124-45. PMID: 22080599
  9. Isolation and Structural Elucidation of Brevibacillin, an Antimicrobial Lipopeptide from Brevibacillus laterosporus That Combats Drug-Resistant Gram-Positive Bacteria.  |  Yang, X., et al. 2016. Appl Environ Microbiol. 82: 2763-2772. PMID: 26921428
  10. Isolation and Characterization of Two Novel Nematicidal Depsipeptides from an Imperfect Fungus, Strain D1084.  |  Kawazu, K., et al. 1993. Biosci Biotechnol Biochem. 57: 98-101. PMID: 27316880
  11. Phaeosphamides A and B, Cytotoxic Cyclodecadepsipeptides from the Mangrove-Derived Fungus Phaeosphaeriopsis sp. S296.  |  Niu, S., et al. 2022. Mar Drugs. 20: PMID: 36286415
  12. Hydroxy acid metabolites of branched-chain amino acids in amniotic fluid.  |  Jakobs, C., et al. 1984. Clin Chim Acta. 140: 157-66. PMID: 6467607
  13. Isolation, structures, and antifungal activities of new aureobasidins.  |  Yoshikawa, Y., et al. 1993. J Antibiot (Tokyo). 46: 1347-54. PMID: 8226313

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-hydroxy-3-methylpentanoic acid, 50 mg

sc-396749
50 mg
$121.00

2-hydroxy-3-methylpentanoic acid, 100 mg

sc-396749A
100 mg
$218.00