Molecular structure of 2-Hydroxy-3-methylbutyric acid, CAS Number: 4026-18-0
2-Hydroxy-3-methylbutyric acid (CAS 4026-18-0)
Alternate Names:
2-Hydroxyisovaleric acid
CAS Number:
4026-18-0
Purity:
≥98%
Molecular Weight:
118.13
Molecular Formula:
C5H10O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
2-Hydroxy-3-methylbutyric acid is an intermediate in the microbial metabolism of hydrogen fluoride and caproic acid. It has diagnostic value for identifying probiotic bacteria. This acid has been observed to induce cell lysis, potentially due to its ability to enhance polymerase chain reaction (PCR). It is utilized as an internal standard for the analysis of ethylene glycol (EG) and γ-hydroxybutyrate (GHB) in whole blood. Additionally, 2-Hydroxy-3-methylbutyric Acid is used as a marker in chemical diagnosis of organic aciduria and other inborn errors. It is also used as a metabolomic biomarker in preeclampsia.
2-Hydroxy-3-methylbutyric acid (CAS 4026-18-0) References
- Improved procedure for the analysis of gamma-hydroxybutyrate and ethylene glycol in whole blood. | Pan, YM., et al. 2001. J Anal Toxicol. 25: 328-32. PMID: 11499886
- Exceptional chiral recognition of racemic carboxylic acids by calix[4]arenes bearing optically pure alpha,beta-amino alcohol groups. | Zheng, YS. and Zhang, C. 2004. Org Lett. 6: 1189-92. PMID: 15070294
- Multidimensional chromatographic approach applied to the identification of novel aroma compounds in wine. Identification of ethyl cyclohexanoate, ethyl 2-hydroxy-3-methylbutyrate and ethyl 2-hydroxy-4-methylpentanoate. | Campo, E., et al. 2006. J Chromatogr A. 1137: 223-30. PMID: 17069823
- Prepregnant Obesity of Mothers in a Multiethnic Cohort Is Associated with Cord Blood Metabolomic Changes in Offspring. | Schlueter, RJ., et al. 2020. J Proteome Res. 19: 1361-1374. PMID: 31975597
- Serum metabolite profiles as potential biochemical markers in young adults with community-acquired pneumonia cured by moxifloxacin therapy. | Zhou, B., et al. 2020. Sci Rep. 10: 4436. PMID: 32157124
- Novel Biomarkers of Habitual Alcohol Intake and Associations With Risk of Pancreatic and Liver Cancers and Liver Disease Mortality. | Loftfield, E., et al. 2021. J Natl Cancer Inst. 113: 1542-1550. PMID: 34010397
- Lactobacillus paracasei BD5115-Derived 2-Hydroxy-3-Methylbutyric Acid Promotes Intestinal Epithelial Cells Proliferation by Upregulating the MYC Signaling Pathway. | Qiao, Z., et al. 2022. Front Nutr. 9: 799053. PMID: 35369066
- A sensitive and accurate GC-MS method for analyzing microbial metabolites short chain fatty acids and their hydroxylated derivatives in newborn fecal samples. | Xia, F., et al. 2023. J Pharm Biomed Anal. 223: 115148. PMID: 36403347
- Propionyl-CoA carboxylase deficiency: case report, effect of low-protein diet and identification of 3-oxo-2-methylvaleric acid 3-hydroxy-2-methylvaleric acid, and maleic acid in urine. | Bergstrøm, T., et al. 1981. Scand J Clin Lab Invest. 41: 117-26. PMID: 7313494
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Hydroxy-3-methylbutyric acid, 1 g | sc-238069 | 1 g | $102.00 |