Date published: 2026-3-12

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2-Fluoropyridine (CAS 372-48-5)

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CAS Number:
372-48-5
Molecular Weight:
97.09
Molecular Formula:
C5H4FN
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Fluoropyridine is known to be a useful building block in the synthesis of agrochemicals. It is used as a reagent in organic chemistry reactions, particularly in the formation of carbon-carbon and carbon-heteroatom bonds. 2-Fluoropyridine is an effective precursor in the preparation of heterocyclic compounds. 2-Fluoropyridine can be used to probe the reactivity and selectivity of different reactions.


2-Fluoropyridine (CAS 372-48-5) References

  1. Aminoborohydrides 15. The first mild and efficient method for generating 2-(dialkylamino)-pyridines from 2-fluoropyridine.  |  Thomas, S., et al. 2003. Org Lett. 5: 3867-70. PMID: 14535730
  2. Selective functionalization of 2-fluoropyridine, 2,3-difluoropyridine, and 2,5-difluoropyridine at each vacant position.  |  Bobbio, C. and Schlosser, M. 2005. J Org Chem. 70: 3039-45. PMID: 15822962
  3. Electronic spectra of hydrogen-bonded 2-fluoropyridine clusters with water in a supersonic free jet.  |  Nibu, Y., et al. 2006. J Phys Chem A. 110: 6047-53. PMID: 16671674
  4. Infrared spectroscopy of hydrogen-bonded 2-fluoropyridine-water clusters in supersonic jets.  |  Nibu, Y., et al. 2006. J Phys Chem A. 110: 9627-32. PMID: 16884196
  5. Microwave rotational spectra and structures of 2-fluoropyridine and 3-fluoropyridine.  |  van Dijk, CW., et al. 2012. J Phys Chem A. 116: 4082-8. PMID: 22443222
  6. 2-Fluoropyridine prosthetic compounds for the 18F labeling of bombesin analogues.  |  Inkster, J., et al. 2013. Bioorg Med Chem Lett. 23: 3920-6. PMID: 23683595
  7. Vibrationally resolved NEXAFS at C and N K-edges of pyridine, 2-fluoropyridine and 2,6-difluoropyridine: A combined experimental and theoretical assessment.  |  Baiardi, A., et al. 2015. J Chem Phys. 143: 204102. PMID: 26627945
  8. Synthesis of N-alkylated 2-pyridones through Pummerer type reactions of activated sulfoxides and 2-fluoropyridine derivatives.  |  Hu, G., et al. 2018. Org Biomol Chem. 16: 4151-4158. PMID: 29785444
  9. Theory meets experiment for unravelling the C1s X-ray photoelectron spectra of pyridine, 2-fluoropyridine, and 2,6-difluoropyridine.  |  Mendolicchio, M., et al. 2019. J Chem Phys. 151: 124105. PMID: 31575180
  10. Access to 2-pyridinylamide and imidazopyridine from 2-fluoropyridine and amidine hydrochloride.  |  Li, Y., et al. 2020. Org Biomol Chem. 18: 9292-9299. PMID: 33164006
  11. Tf2O/TTBP (2,4,6-Tri-tert-butylpyrimidine): An Alternative Amide Activation System for the Direct Transformations of Both Tertiary and Secondary Amides.  |  He, Q., et al. 2021. J Org Chem. 86: 16300-16314. PMID: 34499513
  12. Synthesis of 1-(1-Arylvinyl)pyridin-2(1H)-ones from Ketones and 2-Fluoropyridine.  |  Kawamoto, T., et al. 2021. J Org Chem. 86: 13783-13789. PMID: 34547204
  13. Valence molecular orbitals and cationic structures of 2-fluoropyridine by high-resolution ion spectroscopy and Franck-Condon fitting.  |  Lee, YR. and Kwon, CH. 2022. J Chem Phys. 157: 154306. PMID: 36272779

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Fluoropyridine, 10 g

sc-238055
10 g
$34.00