Date published: 2025-11-3

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2-Fluoropalmitic acid (CAS 89270-22-4)

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Alternate Names:
2-fluorohexadecanoic acid
Application:
2-Fluoropalmitic acid is an inhibitor of palmityl-CoA biosynthesis resulting in blockade of protein palmitoylation
CAS Number:
89270-22-4
Purity:
>98%
Molecular Weight:
274.42
Molecular Formula:
C16H31FO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Fluoropalmitic acid is a fluorinated analog of palmitic acid, which has the interest of researchers due to its unique biochemical properties. It is particularly useful in the study of fatty acid metabolism and enzyme specificity, as the introduction of a fluorine atom can affect the substrate′s interaction with enzymes such as fatty acid synthase and elongases. Biochemists use 2-fluoropalmitic acid to probe the specificity and mechanism of these enzymes, as the fluorine atom can act as a probe due to its electronegative character, providing insights into the structural requirements for enzyme activity. The compound is also used in metabolic labeling studies to trace the incorporation of fatty acids into complex lipids and to examine the alteration of lipid dynamics within cellular membranes. In addition, 2-fluoropalmitic acid serves as a tool to investigate the role of saturated fatty acids in cellular signaling pathways and membrane biophysics, given that the presence of fluorine can influence the biophysical properties of lipid bilayers.


2-Fluoropalmitic acid (CAS 89270-22-4) References

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  7. G protein-membrane interactions I: Gαi1 myristoyl and palmitoyl modifications in protein-lipid interactions and its implications in membrane microdomain localization.  |  Álvarez, R., et al. 2015. Biochim Biophys Acta. 1851: 1511-20. PMID: 26253820
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Fluoropalmitic acid, 5 mg

sc-202881
5 mg
$85.00

2-Fluoropalmitic acid, 10 mg

sc-202881A
10 mg
$156.00

2-Fluoropalmitic acid, 25 mg

sc-202881B
25 mg
$344.00

2-Fluoropalmitic acid, 50 mg

sc-202881C
50 mg
$643.00