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2-Fluoroethylamine hydrochloride (CAS 460-08-2)

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Alternate Names:
2-fluoroethan-1-amine hydrochloride
CAS Number:
460-08-2
Purity:
≥95%
Molecular Weight:
99.54
Molecular Formula:
C2H6FN•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Fluoroethylamine hydrochloride, or 2-Fluoroethanamine hydrochloride, is an amine compound that falls into the category of organic compounds. It is obtained through the reaction between 2-fluoroethanol and hydrogen chloride. This compound has been the subject of extensive scientific research due to its diverse biochemical effects and has shown promising applications in various fields.


2-Fluoroethylamine hydrochloride (CAS 460-08-2) References

  1. The observation of a large gauche preference when 2-fluoroethylamine and 2-fluoroethanol become protonated.  |  Briggs, CR., et al. 2004. Org Biomol Chem. 2: 732-40. PMID: 14985814
  2. Structure-based design of 7-carbamate analogs of geldanamycin.  |  Rastelli, G., et al. 2005. Bioorg Med Chem Lett. 15: 5016-21. PMID: 16165354
  3. Rapid exchange of fluoroethylamine via the Rhesus complex in human erythrocytes: 19F NMR magnetization transfer analysis showing competition by ammonia and ammonia analogues.  |  Szekely, D., et al. 2006. Biochemistry. 45: 9354-61. PMID: 16866382
  4. Conformational preferences and basicities of monofluorinated cyclopropyl amines in comparison to cyclopropylamine and 2-fluoroethylamine.  |  Hyla-Kryspin, I., et al. 2008. Org Biomol Chem. 6: 4167-75. PMID: 18972047
  5. Fluorine conformational effects in organocatalysis: an emerging strategy for molecular design.  |  Zimmer, LE., et al. 2011. Angew Chem Int Ed Engl. 50: 11860-71. PMID: 21953782
  6. Improving the capture of CO2 by substituted monoethanolamines: electronic effects of fluorine and methyl substituents.  |  Gangarapu, S., et al. 2012. Chemphyschem. 13: 3973-80. PMID: 22965750
  7. Conformational analysis of 2,2-difluoroethylamine hydrochloride: double gauche effect.  |  Silla, JM., et al. 2014. Beilstein J Org Chem. 10: 877-82. PMID: 24778743
  8. Direct Brønsted analysis of the restoration of activity to a mutant enzyme by exogenous amines.  |  Toney, MD. and Kirsch, JF. 1989. Science. 243: 1485-8. PMID: 2538921
  9. Amyloid beta protein enhances the survival of hippocampal neurons in vitro.  |  Whitson, JS., et al. 1989. Science. 243: 1488-90. PMID: 2928783
  10. Stereocontrolled Synthesis of Functionalized Azaheterocycles from Carbocycles through Oxidative Ring Opening/Reductive Ring Closing Protocols.  |  Kiss, L., et al. 2020. Chem Rec. 20: 120-141. PMID: 31250972
  11. Regulating Reversible Phase Transition Behaviors by Poly-H/F Substitution in Hybrid Perovskite-Like 2[CH2FCH2NH3]·[CdCl4].  |  Song, N., et al. 2020. ACS Omega. 5: 6773-6780. PMID: 32258912
  12. Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin.  |  Dekan, Z., et al. 2021. Chem Sci. 12: 4057-4062. PMID: 34163676
  13. Strained Ammonium Precursors for Radiofluorinations.  |  Reissig, F. and Mamat, C. 2022. ChemistryOpen. 11: e202200039. PMID: 35736542
  14. Alkylating activity of 1,3-bis(2-chloroethyl)-1-nitrosourea and related compounds.  |  Wheeler, GP. and Chumley, S. 1967. J Med Chem. 10: 259-61. PMID: 6034073
  15. Studies on synthesis and anticancer activity of selected N-(2-fluoroethyl)-N-nitrosoureas.  |  Johnston, TP., et al. 1984. J Med Chem. 27: 1422-6. PMID: 6492072

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Fluoroethylamine hydrochloride, 1 g

sc-230346
1 g
$40.00

2-Fluoroethylamine hydrochloride, 5 g

sc-230346A
5 g
$115.00

2-Fluoroethylamine hydrochloride, 10 g

sc-230346B
10 g
$170.00

2-Fluoroethylamine hydrochloride, 25 g

sc-230346C
25 g
$345.00

2-Fluoroethylamine hydrochloride, 100 g

sc-230346D
100 g
$1252.00