Date published: 2025-10-16

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2-Fluorobenzaldehyde (CAS 446-52-6)

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CAS Number:
446-52-6
Purity:
≥97%
Molecular Weight:
124.11
Molecular Formula:
C7H5FO
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Fluorobenzaldehyde is a chemical compound that functions as a building block in organic synthesis. It is used as a precursor in the production of various agrochemicals, and fine chemicals. In the development setting, 2-Fluorobenzaldehyde acts as a key intermediate in the synthesis of complex organic molecules, allowing for the introduction of a fluorine atom into the molecular structure. Its mechanism of action involves participating in a range of chemical reactions, including nucleophilic addition, condensation, and substitution reactions. 2-Fluorobenzaldehyde plays a role in the modification of organic molecules, enabling the creation of diverse chemical entities with unique properties. Its functional role lies in its ability to serve as a versatile starting material for the preparation of fluorinated compounds, contributing to the advancement of chemical synthesis and the development of new materials.


2-Fluorobenzaldehyde (CAS 446-52-6) References

  1. Inhibitory effects of fluorobenzaldehydes on the activity of mushroom tyrosinase.  |  Huang, XH., et al. 2006. J Enzyme Inhib Med Chem. 21: 413-8. PMID: 17059174
  2. Investigations into the use of a polyfluorooctanol as an auxiliary component for an aldol reaction.  |  Eames, J. and Khanom, H. 2004. Molecules. 9: 266-77. PMID: 18007430
  3. Unusual through-space, TS, pathway for the transmission of J(FHf) coupling: 2-fluorobenzaldehyde study case.  |  Favaro, DC., et al. 2013. J Phys Chem A. 117: 7939-45. PMID: 23895141
  4. Catalytic scope of the thiamine-dependent multifunctional enzyme cyclohexane-1,2-dione hydrolase.  |  Loschonsky, S., et al. 2014. Chembiochem. 15: 389-92. PMID: 24436243
  5. One-pot synthesis of benzo[4,5]imidazo[1,2-a]quinazoline derivatives via facile transition-metal-free tandem process.  |  Fang, S., et al. 2014. ACS Comb Sci. 16: 328-32. PMID: 24919956
  6. Selective oxidation and N-coupling by purified laccase of xylaria polymorpha MTCC-1100.  |  Chaurasia, PK., et al. 2014. Bioorg Khim. 40: 491-6. PMID: 25898759
  7. Fourier Transform Microwave Spectroscopic and ab Initio Study of the Rotamers of 2-Fluorobenzaldehyde and 3-Fluorobenzaldehyde.  |  Sun, W., et al. 2018. J Phys Chem A. 122: 2060-2068. PMID: 29406715
  8. Facile Route to the Synthesis of 1,3-Diazahetero-Cycle-Fused [1,2-a]Quinoline Derivatives via Cascade Reactions.  |  Chen, L., et al. 2018. ACS Omega. 3: 1126-1136. PMID: 31457955
  9. Stereoselective Synthesis of the IDO Inhibitor Navoximod.  |  St-Jean, F., et al. 2022. J Org Chem. 87: 4955-4960. PMID: 35317556

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Fluorobenzaldehyde, 10 g

sc-238049
10 g
$24.00