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2-Ethylhexyl 4-Methoxycinnamate (CAS 5466-77-3)

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Alternate Names:
Octinoxate; 4-Methoxycinnamic acid 2-ethylhexyl ester; Octyl methoxycinnamate
Application:
2-Ethylhexyl 4-Methoxycinnamate is is an UV induced cyclobutane pyrimidine dimer (CDP) formation inhibitior
CAS Number:
5466-77-3
Molecular Weight:
290.40
Molecular Formula:
C18H26O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

2-Ethylhexyl 4-Methoxycinnamate is widely used in research focused on organic ultraviolet (UV) filters due to its ability to absorb UV-B radiation. In studies pertaining to environmental chemistry, it is a key subject in examining the persistence and ecological impact of UV filters found in personal care products that enter aquatic systems. It serves as a model compound in studies aiming to improve the photostability and efficacy of UV absorbers, which is essential for enhancing the performance of materials exposed to sunlight. In the field of polymer science, 2-Ethylhexyl 4-Methoxycinnamate is investigated for its incorporation into polymers to prevent UV-induced degradation.


2-Ethylhexyl 4-Methoxycinnamate (CAS 5466-77-3) References

  1. Transdermal penetration of UV filters.  |  Klinubol, P., et al. 2008. Skin Pharmacol Physiol. 21: 23-9. PMID: 17912021
  2. Measurements of octanol-air partition coefficients, vapor pressures and vaporization enthalpies of the (E) and (Z) isomers of the 2-ethylhexyl 4-methoxycinnamate as parameters of environmental impact assessment.  |  Pegoraro, CN., et al. 2015. Chemosphere. 138: 546-52. PMID: 26210018
  3. Formation of chlorinated breakdown products during degradation of sunscreen agent, 2-ethylhexyl-4-methoxycinnamate in the presence of sodium hypochlorite.  |  Gackowska, A., et al. 2016. Environ Sci Pollut Res Int. 23: 1886-97. PMID: 26408113
  4. The effect of UV-filters on the viability of neuroblastoma (SH-SY5Y) cell line.  |  Broniowska, Ż., et al. 2016. Neurotoxicology. 54: 44-52. PMID: 26965011
  5. Estimation of physicochemical properties of 2-ethylhexyl-4-methoxycinnamate (EHMC) degradation products and their toxicological evaluation.  |  Gackowska, A., et al. 2018. Environ Sci Pollut Res Int. 25: 16037-16049. PMID: 29594898
  6. Two-generation exposure to 2-ethylhexyl 4-methoxycinnamate (EHMC) in Japanese medaka (Oryzias latipes) and its reproduction and endocrine related effects.  |  Lee, I., et al. 2019. Chemosphere. 228: 478-484. PMID: 31051350
  7. Analysis of photokinetics of 2'-ethylhexyl-4-methoxycinnamate in sunscreens.  |  Herzog, B., et al. 2019. Photochem Photobiol Sci. 18: 1773-1781. PMID: 31112187
  8. Alginate microparticles as carriers for the UV filter 2-ethylhexyl 4-methoxycinnamate: Influence on photostability.  |  Duarte, J., et al. 2019. Int J Cosmet Sci. 41: 585-593. PMID: 31509264
  9. Effects of Sulfamethoxazole and 2-Ethylhexyl-4-Methoxycinnamate on the Dissimilatory Nitrate Reduction Processes and N2O Release in Sediments in the Yarlung Zangbo River.  |  Xu, H., et al. 2020. Int J Environ Res Public Health. 17: PMID: 32168922
  10. Effects of 2-ethylhexyl-4-methoxycinnamate (EHMC) on thyroid hormones and genes associated with thyroid, neurotoxic, and nephrotoxic responses in adult and larval zebrafish (Danio rerio).  |  Chu, S., et al. 2021. Chemosphere. 263: 128176. PMID: 33297144
  11. Biodegradation of 2-ethylhexyl-4-methoxycinnamate in river sediments and its impact on microbial communities.  |  Zhang, P., et al. 2021. J Environ Sci (China). 104: 307-316. PMID: 33985734
  12. Relationship between the ability of sunscreens containing 2-ethylhexyl-4'-methoxycinnamate to protect against UVR-induced inflammation, depletion of epidermal Langerhans (Ia+) cells and suppression of alloactivating capacity of murine skin in vivo.  |  Walker, SL., et al. 1994. J Photochem Photobiol B. 22: 29-36. PMID: 8151453
  13. Sunscreen allergy in Singapore.  |  Ang, P., et al. 1998. Am J Contact Dermat. 9: 42-4. PMID: 9471986

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Ethylhexyl 4-Methoxycinnamate, 25 ml

sc-288108
25 ml
$56.00

2-Ethylhexyl 4-Methoxycinnamate, 500 ml

sc-288108A
500 ml
$357.00