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2-Ethoxyethanol (CAS 110-80-5)

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Alternate Names:
Ethylene glycol monoethyl ether
CAS Number:
110-80-5
Molecular Weight:
90.12
Molecular Formula:
C4H10O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Ethoxyethanol, also known as ethyl cellosolve, is an organic solvent with the chemical formula C4H10O2, identifiable under CAS number 110-80-5. This chemical is a clear, colorless liquid bearing a mild, sweet odor, and is notably miscible with water, alcohols, and ethers, thereby highlighting its role as a versatile solvent in industrial applications. Its molecular structure consists of an ethanol backbone where an ethoxy group replaces one hydrogen atom, which significantly alters its physical and chemical properties compared to its parent compounds. In research environments, 2-ethoxyethanol is primarily utilized for its solvent properties, particularly in the formulation of inks, dyes, and stains. It efficiently dissolves both polar and non-polar substances, making it invaluable in the synthesis and application of various chemical products. Furthermore, its moderate evaporation rate and ability to lower the viscosity of mixtures enhance its utility in the preparation of coating solutions. In the realm of polymer science, 2-ethoxyethanol is used to facilitate reactions and manipulate polymer chains, especially in processes where uniform application and smooth finish are crucial. Its application extends into the field of electronics as well, where it is used in the cleaning and preparing of components where precision and cleanliness are paramount. As such, 2-ethoxyethanol′s role in research and industrial applications is primarily defined by its efficacy as a solvent and its contribution to the quality and stability of final products.


2-Ethoxyethanol (CAS 110-80-5) References

  1. NTP technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice.  |  Dieter, M. 1993. Toxic Rep Ser. 26: 1-G15. PMID: 12209180
  2. Derivatization procedure and HPLC determination of 2-ethoxyethanol in cosmetic samples.  |  Mariani, E., et al. 1999. Int J Cosmet Sci. 21: 199-205. PMID: 18505541
  3. Testicular gene expression profiling following 2-methoxyethanol and 2-ethoxyethanol exposure in male rats reveals abnormal expression of the actin binding protein cortactin in degenerating spermatocytes.  |  Tonkin, EG., et al. 2009. Toxicol Lett. 190: 193-201. PMID: 19643169
  4. Testicular effect of a mixture of 2-methoxyethanol and 2-ethoxyethanol in rats.  |  Starek-Świechowicz, B., et al. 2015. Pharmacol Rep. 67: 289-93. PMID: 25712652
  5. Use of 2-ethoxyethanol and alpha-amylase in the neutral detergent fiber method of feed analysis.  |  Cherney, DJ., et al. 1989. J Dairy Sci. 72: 3079-84. PMID: 2625497
  6. The effects of 2-methoxyethanol and 2-ethoxyethanol on hematological changes induced by 2-butoxyethanol.  |  Starek-Świechowicz, B., et al. 2015. Med Pr. 66: 303-15. PMID: 26325043
  7. Reticulocytosis in screen-printing workers exposed to 2-butoxyethanol and 2-ethoxyethanol.  |  Song, SH., et al. 2017. Ann Occup Environ Med. 29: 54. PMID: 29152309
  8. Thermal Degradation and Bimolecular Decomposition of 2-Ethoxyethanol in Binary Ethanol and Isobutanol Solvent Mixtures: A Computational Mechanistic Study.  |  Al Omari, RH., et al. 2021. ACS Omega. 6: 13365-13374. PMID: 34056483
  9. Atmospheric Photo-Oxidation of 2-Ethoxyethanol: Autoxidation Chemistry of Glycol Ethers.  |  Yu, H., et al. 2023. J Phys Chem A. 127: 9564-9579. PMID: 37934888

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Ethoxyethanol, 1 L

sc-238024
1 L
$119.00

2-Ethoxyethanol, 4 L

sc-238024A
4 L
$170.00