Date published: 2025-12-5

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2-(Diphenylphosphino)benzaldehyde (CAS 50777-76-9)

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Alternate Names:
(2-Formylphenyl)diphenylphosphine, o-(Diphenylphosphino)benzaldehyde
Application:
2-(Diphenylphosphino)benzaldehyde is a useful biochemical for proteomics research
CAS Number:
50777-76-9
Molecular Weight:
290.30
Molecular Formula:
C19H15OP
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-(Diphenylphosphino)benzaldehyde (DPPB) is an organophosphorus compound that finds extensive applications in organic synthesis, and biochemistry. Its exceptional Lewis acidity and the capacity to effectively bind to and activate diverse substrates make it a highly valuable reagent. It exhibits catalytic properties in organic reactions, particularly in the synthesis of heterocycles and organometallic compounds. Additionally, it significantly contributes to the synthesis of peptides, peptidomimetics, and chiral compounds. The strong Lewis acidity of 2-(Diphenylphosphino)benzaldehyde enables its efficient binding and activation of a wide range of substrates. This unique characteristic makes it an invaluable tool in the synthesis of diverse organic compounds and pharmaceuticals. Furthermore, its catalytic capabilities enable the facilitation of various reactions, such as the synthesis of heterocycles and organometallic compounds.


2-(Diphenylphosphino)benzaldehyde (CAS 50777-76-9) References

  1. Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino)benzaldehyde and ethyl hydrazinoacetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes.  |  Malesević, N., et al. 2006. J Inorg Biochem. 100: 1811-8. PMID: 16938348
  2. Synthesis, characterization and biological activity of three square-planar complexes of Ni(II) with ethyl (2E)-2-[2-(diphenylphosphino)benzylidene]hydrazinecarboxylate and monodentate pseudohalides.  |  Milenković, M., et al. 2013. Eur J Med Chem. 68: 111-20. PMID: 23973823
  3. Imino-phosphine palladium(II) and platinum(II) complexes: synthesis, molecular structures and evaluation as antitumor agents.  |  Motswainyana, WM., et al. 2013. J Inorg Biochem. 129: 112-8. PMID: 24099695
  4. Synthesis, characterization, DFT calculation and biological activity of square-planar Ni(II) complexes with tridentate PNO ligands and monodentate pseudohalides. Part II.  |  Milenković, M., et al. 2014. Eur J Med Chem. 87: 284-97. PMID: 25262049
  5. Investigation of antitumor potential of Ni(II) complexes with tridentate PNO acylhydrazones of 2-(diphenylphosphino)benzaldehyde and monodentate pseudohalides.  |  Čobeljić, B., et al. 2016. J Biol Inorg Chem. 21: 145-62. PMID: 26612231

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-(Diphenylphosphino)benzaldehyde, 1 g

sc-254085
1 g
$45.00