Date published: 2025-10-20

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2-Diphenylphosphino-1-naphthoic acid (CAS 178176-80-2)

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CAS Number:
178176-80-2
Molecular Weight:
356.36
Molecular Formula:
C23H17O2P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Diphenylphosphino-1-naphthoic acid (DPN) is an extensively investigated organic compound. As an aromatic phosphonic acid, 2-Diphenylphosphino-1-naphthoic acid can be synthesized from diverse starting materials and exhibits a structure comprising two benzene rings linked by a phosphonate group. Notably, 2-Diphenylphosphino-1-naphthoic acid displays a broad range of utility in biochemistry, organic chemistry, and materials science. Within the realm of biochemistry, 2-Diphenylphosphino-1-naphthoic acid has emerged as a valuable reagent for synthesizing phosphonates, components employed in peptide and protein synthesis. In organic chemistry, 2-Diphenylphosphino-1-naphthoic acid has proven its worth as a catalyst for producing diverse organic compounds. In the realm of materials science, 2-Diphenylphosphino-1-naphthoic acid has been employed as a cross-linking agent, facilitating the synthesis of polymers and other materials. While the precise mechanism of action of 2-Diphenylphosphino-1-naphthoic acid remains partially elusive, it is postulated to involve the formation of a diphosphonate intermediate. This intermediate arises through the reaction of two molecules of 2-Diphenylphosphino-1-naphthoic acid with a proton, subsequently yielding a stable product upon the addition of a base. The mechanism of action of 2-Diphenylphosphino-1-naphthoic acid is believed to exhibit similarities to that of other phosphonates, including phosphonic acid and phosphonates.


2-Diphenylphosphino-1-naphthoic acid (CAS 178176-80-2) References

  1. Dynamic kinetic asymmetric cycloadditions of isocyanates to vinylaziridines.  |  Trost, BM. and Fandrick, DR. 2003. J Am Chem Soc. 125: 11836-7. PMID: 14505403
  2. Conversion of aryl azides to O-alkyl imidates via modified Staudinger ligation.  |  Restituyo, JA., et al. 2003. Org Lett. 5: 4357-60. PMID: 14601999
  3. Dynamic kinetic asymmetric transformation of diene monoepoxides: A practical asymmetric synthesis of vinylglycinol, vigabatrin, and ethambutol  |  Trost, B. M., Bunt, R. C., Lemoine, R. C., & Calkins, T. L. 2000. Journal of the American Chemical Society. 122(25): 5968-5976.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Diphenylphosphino-1-naphthoic acid, 1 g

sc-265669
1 g
$195.00