Date published: 2026-2-22

1-800-457-3801

SCBT Portrait Logo
Seach Input

2-Dimethylaminoethanol (CAS 108-01-0)

0.0(0)
Write a reviewAsk a question

Alternate Names:
N,N-Dimethyl-2-hydroxyethylamine, N,N-Dimethylethanolamine, DMEA
CAS Number:
108-01-0
Purity:
≥98%
Molecular Weight:
89.14
Molecular Formula:
C4H11NO
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

2-Dimethylaminoethanol (DMAE), also known as deanol or dimethylethanolamine (DMEA), is an amino alcohol. It is formed as the main product in the amination of ethylene glycol by dimethylamine on alumina supported copper in a continuous fixed-bed reactor. 2-Dimethylaminoethanol is considered a putative precursor of acetylcholine and has been extensively studied for its effects as a skin-firming and anti-wrinkle agent. It has also been investigated for its organic additive properties, particularly in relation to deposition and anti-reflective properties of porous CaF2. In terms of its chemical properties, 2-Dimethylaminoethanol has a clear colorless liquid appearance with a fishlike odor. It has a flash point of 105°F and is less dense than water, with vapors heavier than air. Combustion of 2-Dimethylaminoethanol produces toxic oxides of nitrogen. It serves as a precursor in the production of various other chemicals.Dimethylethanolamine belongs to the class of organic compounds called 1,2-aminoalcohols, characterized by an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom. It exists primarily as a solid and is highly soluble in water. Dimethylethanolamine is weakly acidic, essentially neutral based on its pKa value. Within cells, it is predominantly found in the cytoplasm. It is worth noting that dimethylethanolamine is potentially toxic.


2-Dimethylaminoethanol (CAS 108-01-0) References

  1. Stimulant effect of 2-dimethylaminoethanol; possible precursor of brain acetylcholine.  |  PFEIFFER, CC., et al. 1957. Science. 126: 610-1. PMID: 13467254
  2. Maze performance, emotionality, audiogenic seizure susceptibility in rats and mice treated with 2-dimethylaminoethanol.  |  SMITH, RP. and BEVAN, W. 1957. Proc Soc Exp Biol Med. 96: 382-5. PMID: 13485109
  3. Effect of 2-dimethylaminoethanol on renal hemodynamics.  |  BLACKMORE, WP. 1958. Proc Soc Exp Biol Med. 98: 1-3. PMID: 13554522
  4. 2-Dimethylaminoethanol as a central nervous system stimulant; one aspect of the pharmacology of reserpine.  |  MURPHREE, HB., et al. 1959. Res Publ Assoc Res Nerv Ment Dis. 37: 204-17. PMID: 13646049
  5. Electroencephalographic analysis of the effect of 2-dimethylaminoethanol, choline and atropine on the rabbit brain.  |  GOLDSTEIN, L. 1960. J Pharmacol Exp Ther. 128: 392-6. PMID: 13850775
  6. Occurrence and quantitative determination of 2-dimethylaminoethanol in animal tissue extracts.  |  HONEGGER, CG. and HONEGGER, R. 1959. Nature. 184(Suppl 8): 550-2. PMID: 14402942
  7. The stimulant effect of 2-dimethylaminoethanol (deanol) in human volunteer subjects.  |  MURPHREE, HB., et al. 1960. Clin Pharmacol Ther. 1: 303-10. PMID: 14425373
  8. The role of dimethylaminoethanol in cosmetic dermatology.  |  Grossman, R. 2005. Am J Clin Dermatol. 6: 39-47. PMID: 15675889
  9. The antiwrinkle effect of topical concentrated 2-dimethylaminoethanol involves a vacuolar cytopathology.  |  Morissette, G., et al. 2007. Br J Dermatol. 156: 433-9. PMID: 17300230
  10. Structural characterization and stability of dimethylaminoethanol and dimethylaminoethanol bitartrate for possible use in cosmetic firming.  |  Clares, B., et al. 2010. J Cosmet Sci. 61: 269-78. PMID: 20716435
  11. Fabrication and Characterization of Polyphosphazene/Calcium Phosphate Scaffolds Containing Chitosan Microspheres for Sustained Release of Bone Morphogenetic Protein 2 in Bone Tissue Engineering.  |  Sobhani, A., et al. 2017. Tissue Eng Regen Med. 14: 525-538. PMID: 30603507
  12. A generic gas chromatography method for determination of residual solvents in PET radiopharmaceuticals.  |  Jószai, I., et al. 2022. J Pharm Biomed Anal. 207: 114425. PMID: 34656936
  13. Carbon-11 choline: synthesis, purification, and brain uptake inhibition by 2-dimethylaminoethanol.  |  Rosen, MA., et al. 1985. J Nucl Med. 26: 1424-8. PMID: 3877796
  14. Protection of murine L1210 leukemia and bone marrow progenitor cells against mechlorethamine and inhibition of choline uptake as a structure-activity relationship of 2-dimethylaminoethanol and its analogues.  |  Naujokaitis, SA., et al. 1984. J Pharm Sci. 73: 34-9. PMID: 6694079
  15. Effects of 2-dimethylaminoethanol (Deanol) on the metabolism of choline in plasma.  |  Ceder, G., et al. 1978. J Neurochem. 30: 1293-6. PMID: 670971

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Dimethylaminoethanol, 250 ml

sc-238021
250 ml
$22.00