2-Dimethylamino-6-hydroxypurine (CAS 1445-15-4)
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2-Dimethylamino-6-hydroxypurine is a modified form of the guanine base, which is an essential component of DNA and RNA molecules. Its utilization has been pivotal in investigating the impact of environmental toxins and radiation on DNA damage. Moreover, it has played a role in unraveling the intricate mechanisms underlying DNA repair and replication. Additionally, 2-Dimethylamino-6-hydroxypurine has facilitated the examination of how gene expression influences various cellular processes. In terms of structure, 2-Dimethylamino-6-hydroxypurine closely resembles guanine, albeit with a methyl group replacing one of the hydrogen atoms. This structural variation imparts unique biochemical characteristics to this modified guanine base. Notably, 2-Dimethylamino-6-hydroxypurine is recognized by DNA repair enzymes, making it useful for investigating DNA damage and repair processes.
2-Dimethylamino-6-hydroxypurine (CAS 1445-15-4) References
- Fluorometric assay of 2-dimethylamino-6-hydroxypurine (dimethylaminoguanine) in the presence of guanine. | UDENFRIEND, S., et al. 1963. Anal Biochem. 5: 258-60. PMID: 13995110
- Studies on soluble ribonucleic acid of rabbit liver. II. Preparation and properties of rabbit-liver soluble RNA. | CANTONI, GL., et al. 1962. Biochim Biophys Acta. 61: 354-67. PMID: 14018363
- THE IDENTIFICATION OF 2-DIMETHYLAMINO-6- HYDROXYPURINE AND ITS RIBONUCLEOSIDE IN URINE OF NORMAL AND LEUKEMIC SUBJECTS. | FINK, K., et al. 1963. Cancer Res. 23: 1824-9. PMID: 14082879
- Matrix isolation infrared studies of nucleic acid constituents: Part 4. Guanine and 9-methylguanine monomers and their keto-enol tautomerism | Krystyna Szczepaniak 1, Marian Szczesniak. 1987. Journal of Molecular Structure. 156: 29-42.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Dimethylamino-6-hydroxypurine, 25 mg | sc-206445 | 25 mg | $176.00 |