Date published: 2025-11-3

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2-(Dicyclohexylphosphino)biphenyl (CAS 247940-06-3)

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Alternate Names:
(2-Biphenyl)dicyclohexylphosphine
CAS Number:
247940-06-3
Molecular Weight:
350.48
Molecular Formula:
C24H31P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-(Dicyclohexylphosphino)biphenyl is ligand for amination of triflates and aryl halides.(1) Optimal ligand for a novel amination reaction (Buchwald reaction)(2) 2-(Dicyclohexylphosphino)biphenyl, a synthetic chemical compound, has found diverse applications in scientific research. Being a cyclic phosphonate derivative of cyclohexanol, this colorless, odorless, and tasteless solid holds a distinct appeal for laboratory use. In scientific research, 2-(Dicyclohexylphosphino)biphenyl has proven invaluable. It serves as an excellent model compound for delving into protein-ligand interactions, thus aiding in the study of small molecule effects on protein folding. Moreover, researchers have utilized 2-(Dicyclohexylphosphino)biphenyl to gain insights into protein structures, as well as to unravel the mechanism of action behind various drugs. Additionally, the compound has been a key tool in assessing how environmental factors influence protein structure and function. The interaction between 2-(Dicyclohexylphosphino)biphenyl and proteins primarily occurs through hydrogen bonding and hydrophobic interactions, resulting in high-affinity and specific protein binding. This unique bonding alters the structure and function of proteins, paving the way for exciting possibilities in scientific exploration.


2-(Dicyclohexylphosphino)biphenyl (CAS 247940-06-3) References

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  2. Electronic effects in the pt-catalyzed cycloisomerization of propargylic esters: synthesis of 2,3-disubstituted indolizines as a mechanistic probe.  |  Hardin, AR. and Sarpong, R. 2007. Org Lett. 9: 4547-50. PMID: 17845052
  3. Efficient Pd-catalyzed coupling of tautomerizable heterocycles with terminal alkynes via C-OH bond activation using PyBrOP.  |  Shi, C. and Aldrich, CC. 2010. Org Lett. 12: 2286-9. PMID: 20411949
  4. Palladium-catalyzed indole, pyrrole, and furan arylation by aryl chlorides.  |  Nadres, ET., et al. 2011. J Org Chem. 76: 471-83. PMID: 21192652
  5. Palladium-Catalyzed Aryl Amination Reactions of 6-Bromo- and 6-Chloropurine Nucleosides.  |  Thomson, PF., et al. 2010. Adv Synth Catal. 352: 1728-1735. PMID: 21818182
  6. Copper-catalyzed β-boration of α,β-unsaturated carbonyl compounds with tetrahydroxydiborane.  |  Molander, GA. and McKee, SA. 2011. Org Lett. 13: 4684-7. PMID: 21819097
  7. KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines.  |  Lavrado, J., et al. 2015. Sci Rep. 5: 9696. PMID: 25853628
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  10. Ruthenium(0)-Catalyzed Cycloaddition of 1,2-Diols, Ketols, or Diones via Alcohol-Mediated Hydrogen Transfer.  |  Sato, H., et al. 2018. Angew Chem Int Ed Engl. 57: 3012-3021. PMID: 29068505
  11. Irradiation-induced palladium-catalyzed decarboxylative desaturation enabled by a dual ligand system.  |  Cheng, WM., et al. 2018. Nat Commun. 9: 5215. PMID: 30523253
  12. Optimisation of a key cross-coupling reaction towards the synthesis of a promising antileishmanial compound.  |  Velasco, RF., et al. 2019. Tetrahedron Lett. 60: 1243-1247. PMID: 31057189
  13. Site-Selective Silver-Catalyzed C-H Bond Deuteration of Five-Membered Aromatic Heterocycles and Pharmaceuticals.  |  Tlahuext-Aca, A. and Hartwig, JF. 2021. ACS Catal. 11: 1119-1127. PMID: 35586574

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-(Dicyclohexylphosphino)biphenyl, 1 g

sc-254158
1 g
$45.00

2-(Dicyclohexylphosphino)biphenyl, 5 g

sc-254158A
5 g
$209.00