Date published: 2026-1-20

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2-Di-tert-butylphosphino-3,4,5,6-tetramethyl-2′,4′,6′-triisopropyl-1,1′-biphenyl (CAS 857356-94-6)

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Alternate Names:
Tetramethyl di-tBuXPhos
Application:
2-Di-tert-butylphosphino-3,4,5,6-tetramethyl-2′,4′,6′-triisopropyl-1,1′-biphenyl is a ligand for palladium-catalyzed amidation of aryl chlorides
CAS Number:
857356-94-6
Purity:
≥98%
Molecular Weight:
480.75
Molecular Formula:
C33H53P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Di-tert-butylphosphino-3,4,5,6-tetramethyl-2′,4′,6′-triisopropyl-1,1′-biphenyl is a ligand employed in a palladium-catalyzed amidation of aryl chlorides.


2-Di-tert-butylphosphino-3,4,5,6-tetramethyl-2′,4′,6′-triisopropyl-1,1′-biphenyl (CAS 857356-94-6) References

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  2. Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring.  |  Termentzi, A., et al. 2010. Eur J Med Chem. 45: 5833-47. PMID: 20961671
  3. Rh/Pd catalysis with chiral and achiral ligands: domino synthesis of aza-dihydrodibenzoxepines.  |  Friedman, AA., et al. 2013. Angew Chem Int Ed Engl. 52: 9755-8. PMID: 23868558
  4. Gold(I)-catalyzed selective heterocyclization of propargylic thioureas: mechanistic study of competitive gold-activation mode.  |  Jiang, Y., et al. 2015. Chemistry. 21: 7675-81. PMID: 25829336
  5. Deprotometalation-iodolysis and computed CH acidity of 1,2,3- and 1,2,4-triazoles. Application to the synthesis of resveratrol analogues.  |  Nagaradja, E., et al. 2015. Bioorg Med Chem. 23: 6355-63. PMID: 26344592
  6. Bifidenone: Structure-Activity Relationship and Advanced Preclinical Candidate.  |  Huang, Z., et al. 2018. J Med Chem. 61: 6736-6747. PMID: 29995409
  7. Effective Tools for the Metal-Catalyzed Regiodivergent Direct Arylations of (Hetero)arenes.  |  Huang, HY., et al. 2021. Chem Rec. 21: 343-356. PMID: 33332755
  8. Discovery of the Oxadiazine FRM-024: A Potent CNS-Penetrant Gamma Secretase Modulator.  |  Bursavich, MG., et al. 2021. J Med Chem. 64: 14426-14447. PMID: 34550687
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  11. Design and Synthesis of Novel Cereblon Binders for Use in Targeted Protein Degradation.  |  Norris, S., et al. 2023. J Med Chem. 66: 16388-16409. PMID: 37991844
  12. Development of an efficient route toward meiogynin A-inspired dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins  |  Desrat, S., Remeur, C., & Roussi, F. 2015. Organic & biomolecular chemistry. 13(19): 5520-5531.
  13. Reaction Conditions for the Regiodivergent Direct Arylations at C2‐or C5‐Positions of Oxazoles using Phosphine‐Free Palladium Catalysts  |  Shi, X., Soulé, J. F., & Doucet, H. 2019. Advanced Synthesis & Catalysis. 361(20): 4748-4760.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Di-tert-butylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl, 250 mg

sc-251740
250 mg
$92.00