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2-Deoxyribose 5-phosphate sodium salt (CAS 102916-66-5)

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Application:
CAS Number:
102916-66-5
Purity:
≥95%
Molecular Weight:
214.11 (free acid basis)
Molecular Formula:
C5H11O7P•xNa
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Deoxyribose 5-phosphate sodium salt is a 2-deoxyribose salt. It is an intermediate in the biosynthesis of DNA. In cellular processes, it serves as a precursor for the synthesis of deoxyribonucleotides, the building blocks of DNA. It is involved in the pentose phosphate pathway, where it is converted to deoxyribonucleotides through a series of enzymatic reactions Research involving 2-Deoxyribose 5-phosphate sodium salt often focuses on understanding the biosynthesis of DNA and studying the enzymes involved in DNA replication and repair. By manipulating the levels or availability of 2-Deoxyribose 5-phosphate, researchers can investigate its impact on DNA synthesis, cellular proliferation, and related biological processes. Furthermore, the compound may be utilized in enzymatic assays, in vitro studies, and as a substrate for specific enzymes involved in nucleotide metabolism or DNA-related pathways. Its availability as a sodium salt form enhances its solubility and ease of use in experimental applications.


2-Deoxyribose 5-phosphate sodium salt (CAS 102916-66-5) References

  1. Thermotoga maritima 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase: the ancestral eubacterial DAHP synthase?  |  Wu, J., et al. 2003. J Biol Chem. 278: 27525-31. PMID: 12743122
  2. Microbial production of 2-deoxyribose 5-phosphate from acetaldehyde and triosephosphate for the synthesis of 2'-deoxyribonucleosides.  |  Ogawa, J., et al. 2003. Biosci Biotechnol Biochem. 67: 933-6. PMID: 12784646
  3. Construction of deoxyriboaldolase-overexpressing Escherichia coli and its application to 2-deoxyribose 5-phosphate synthesis from glucose and acetaldehyde for 2'-deoxyribonucleoside production.  |  Horinouchi, N., et al. 2003. Appl Environ Microbiol. 69: 3791-7. PMID: 12839746
  4. Excision of sugar-phosphate products at apurinic/apyrimidinic sites by DNA deoxyribophosphodiesterase of Escherichia coli.  |  Sandigursky, M., et al. 1992. Radiat Res. 131: 332-7. PMID: 1332111
  5. Azidothymidine promotes free radical generation by activated macrophages and hydrogen peroxide-iron-mediated oxidation in a cell-free system.  |  Komarov, AM., et al. 2004. Biochim Biophys Acta. 1688: 257-64. PMID: 15062877
  6. Functional and biochemical characterization of a recombinant Arabidopsis thaliana 3-deoxy-D-manno-octulosonate 8-phosphate synthase.  |  Wu, J., et al. 2004. Biochem J. 381: 185-93. PMID: 15070398
  7. Biochemical retrosynthesis of 2'-deoxyribonucleosides from glucose, acetaldehyde, and a nucleobase.  |  Horinouchi, N., et al. 2006. Appl Microbiol Biotechnol. 71: 615-21. PMID: 16283293
  8. One-pot microbial synthesis of 2'-deoxyribonucleoside from glucose, acetaldehyde, and a nucleobase.  |  Horinouchi, N., et al. 2006. Biotechnol Lett. 28: 877-81. PMID: 16786272
  9. Efficient production of 2-deoxyribose 5-phosphate from glucose and acetaldehyde by coupling of the alcoholic fermentation system of Baker's yeast and deoxyriboaldolase-expressing Escherichia coli.  |  Horinouchi, N., et al. 2006. Biosci Biotechnol Biochem. 70: 1371-8. PMID: 16794316
  10. Cloning, expression, and characterization of a new deoxyribose 5-phosphate aldolase from Yersinia sp. EA015.  |  Kim, YM., et al. 2009. Protein Expr Purif. 68: 196-200. PMID: 19505577
  11. Production of 2-deoxyribose 5-phosphate from fructose to demonstrate a potential of artificial bio-synthetic pathway using thermophilic enzymes.  |  Honda, K., et al. 2010. J Biotechnol. 148: 204-7. PMID: 20547190
  12. Selection of a new whole cell biocatalyst for the synthesis of 2-deoxyribose 5-phosphate.  |  Valino, AL., et al. 2012. Appl Biochem Biotechnol. 166: 300-8. PMID: 22057938
  13. Synthesis of Terminal Ribose Analogues of Adenosine 5'-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2.  |  Baszczyňski, O., et al. 2019. J Org Chem. 84: 6143-6157. PMID: 30978018
  14. Substrate specificity of 2-deoxy-D-ribose 5-phosphate aldolase (DERA) assessed by different protein engineering and machine learning methods.  |  Voutilainen, S., et al. 2020. Appl Microbiol Biotechnol. 104: 10515-10529. PMID: 33147349
  15. Synthetic Activity of Recombinant Whole Cell Biocatalysts Containing 2-Deoxy-D-ribose-5-phosphate Aldolase from Pectobacterium atrosepticum.  |  Varela, RF., et al. 2022. Chembiochem. 23: e202200147. PMID: 35476788

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Deoxyribose 5-phosphate sodium salt, 25 mg

sc-213795
25 mg
$122.00

2-Deoxyribose 5-phosphate sodium salt, 100 mg

sc-213795A
100 mg
$350.00