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2-Deoxy-D-glucose 6-phosphate sodium salt (CAS 33068-19-8)

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Application:
2-Deoxy-D-glucose 6-phosphate sodium salt is an intermediate involved in the degredation of glycogen
CAS Number:
33068-19-8
Purity:
≥98%
Molecular Weight:
266.12
Molecular Formula:
C6H12O8P•xNa
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Deoxy-D-glucose 6-phosphate sodium salt is used to study glucose metabolism and glycolysis because it can act as a competitive inhibitor for enzymes that process glucose-6-phosphate. By inhibiting these enzymes, 2-Deoxy-D-glucose 6-phosphate can be used to trace or disrupt metabolic pathways, providing insights into cellular energy production processes and how cells respond to changes in glucose availability. Moreover, the sodium salt form enhances the solubility of the compound in aqueous solutions, facilitating its use in various experimental applications. This property is particularly useful in laboratory experiments involving cellular cultures or biochemical assays where precise control over solute concentrations is required.


2-Deoxy-D-glucose 6-phosphate sodium salt (CAS 33068-19-8) References

  1. Targeting Type 2 Diabetes with C-Glucosyl Dihydrochalcones as Selective Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors: Synthesis and Biological Evaluation.  |  Jesus, AR., et al. 2017. J Med Chem. 60: 568-579. PMID: 28098449
  2. Kinetic analysis of effectors of phosphoenolpyruvate carboxylase from Bryophyllum fedtschenkoi.  |  Pays, AG., et al. 1980. Biochim Biophys Acta. 614: 151-62. PMID: 7397199
  3. The binding of 2-deoxy-D-glucose 6-phosphate to glycogen phosphorylase b: kinetic and crystallographic studies.  |  Oikonomakos, NG., et al. 1995. J Mol Biol. 254: 900-17. PMID: 7500360

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Deoxy-D-glucose 6-phosphate sodium salt, 10 mg

sc-220734
10 mg
$118.00

2-Deoxy-D-glucose 6-phosphate sodium salt, 100 mg

sc-220734A
100 mg
$430.00

2-Deoxy-D-glucose 6-phosphate sodium salt, 250 mg

sc-220734B
250 mg
$604.00

Is 2-Deoxy-D-glucose 6-phosphate sodium salt soluble in Triethanolamine (TEA) solution at pH 8.1?

Asked by: ALOAA
Thank you for your question. This compound is soluble in PBS (pH 7.2) to approximately 10 mg/mL, and we have found the compound to be insoluble in DMF, DMSO, and Ethanol.  Unfortunately, we have not tested the solubility in Triethanolamine (TEA) solution at pH 8.1. 
Answered by: BlakeJ
Date published: 2023-12-01

What is the solubility of this product?

Asked by: SCchem16
Thank you for your question. The solubility for 2-Deoxy-D-glucose 6-phosphate sodium salt is 50mg/ml in water and ~10 mg/ml in PBS (pH 7.2).
Answered by: Technical Support
Date published: 2017-02-03
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Rated 5 out of 5 by from NasrallahNasrallah, FA. et al. (PubMed 23673434) used chemical exchange saturation transfer (CEST) as a signal-amplification mechanism to detect 2-Deoxy-D-glucose 6-phosphate (2DG6P) indirectly in (1)H magnetic resonance imaging (MRI). -SCBT Publication Review
Date published: 2015-04-17
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2-Deoxy-D-glucose 6-phosphate sodium salt is rated 5.0 out of 5 by 1.
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