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2-Deoxy-D-glucose (CAS 154-17-6)

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Alternate Names:
2-Deoxy-D-glucose also known as 2-Deoxy-D-arabinohexose; 2-Deoxyglucose; 2-deoxy-d-arabino-hexos; 2-deoxy-d-glucos; 2-deoxy-d-mannose; 2-deoxy-glucos; 2-desoxy-d-glucose; D-Arabino-2-deoxyhexose; D-2-GLUCODESOSE; 2-DEOXY-D-ARABINOHEXOSE; 2-DEOXYGLUCOSE; 2-Deoxy-D-Arabino; 6-HYDROXYMETHYL-5-METHYL-TETRAHYDRO-PYRAN-2,4,5-TRIOL; D-arabino-Hexose, 2-deoxy-; DEOXY-D-GLUCOSE, 2-(P); (3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal
Application:
2-Deoxy-D-glucose is an apoptosis and HXK inhibitor that lowers ATP levels in cancer cell lines and has shown to be taken up by glial cells incubated with insulin
CAS Number:
154-17-6
Purity:
≥98%
Molecular Weight:
164.16
Molecular Formula:
C6H12O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Deoxy-D-glucose (2-DG) is an apoptosis inhibitor that may act to be taken up by glial cells incubated with insulin. Studies indicate that it has the potential to suppress hypoxia in murine retinal tissue. Additionally, 2-Deoxy-D-glucose has been noted to be a glycolytic inhibitor via indirect inhibition of hexokinase (HXK) which results in endoplasmic reticulum stress. Other experiments suggest that it upregulates autophagy and lowers ATP levels in certain cancer cell lines. 2-Deoxy-D-glucose is an activator of AMPK and an inhibitor of GPI. It is used in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR). 2-Deoxy-D-glucose is also used in the development of anti-cancer strategies that involve radio- and chemo- sensitization and oxidative stress.


2-Deoxy-D-glucose (CAS 154-17-6) References

  1. Effect of 2-deoxy-D-glucose on aminoacids metabolism in rats' cerebral cortex slices.  |  Muller, AP., et al. 2006. Neurochem Res. 31: 417-22. PMID: 16733818
  2. Differential toxic mechanisms of 2-deoxy-D-glucose versus 2-fluorodeoxy-D-glucose in hypoxic and normoxic tumor cells.  |  Kurtoglu, M., et al. 2007. Antioxid Redox Signal. 9: 1383-90. PMID: 17627467
  3. Enhancement of radiation and chemotherapeutic drug responses by 2-deoxy-D-glucose in animal tumors.  |  Gupta, S., et al. 2009. J Cancer Res Ther. 5 Suppl 1: S16-20. PMID: 20009287
  4. Cytotoxicity, radiosensitization, and chemosensitization of tumor cells by 2-deoxy-D-glucose in vitro.  |  Dwarakanath, BS. 2009. J Cancer Res Ther. 5 Suppl 1: S27-31. PMID: 20009290
  5. Protection of normal cells and tissues during radio- and chemosensitization of tumors by 2-deoxy-D-glucose.  |  Farooque, A., et al. 2009. J Cancer Res Ther. 5 Suppl 1: S32-5. PMID: 20009291
  6. 2-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion.  |  Xi, H., et al. 2011. Cancer Chemother Pharmacol. 67: 899-910. PMID: 20593179
  7. Focal, periocular delivery of 2-deoxy-D-glucose as adjuvant to chemotherapy for treatment of advanced retinoblastoma.  |  Piña, Y., et al. 2010. Invest Ophthalmol Vis Sci. 51: 6149-56. PMID: 20702830
  8. 2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy.  |  Zhang, D., et al. 2014. Cancer Lett. 355: 176-83. PMID: 25218591
  9. Effect of 2-deoxy-D-glucose on gellan gum biosynthesis by Sphingomonas paucimobilis.  |  Zhu, G., et al. 2019. Bioprocess Biosyst Eng. 42: 897-900. PMID: 30671627
  10. 2-deoxy D-glucose treatment does not elicit a hair growth response in alopecia areata.  |  Sundberg, JP., et al. 2019. Exp Dermatol. 28: 1091-1093. PMID: 31323149
  11. 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents.  |  Pajak, B., et al. 2019. Int J Mol Sci. 21: PMID: 31905745
  12. 2-Deoxy-D-glucose and combined 2-Deoxy-D-glucose/albendazole exhibit therapeutic efficacy against Echinococcus granulosus protoscoleces and experimental alveolar echinococcosis.  |  Xin, Q., et al. 2022. PLoS Negl Trop Dis. 16: e0010618. PMID: 35849619
  13. Role of 2-deoxy-D-glucose in the inhibition of phagocytosis by mouse peritoneal macrophage.  |  Sung, SS. and Silverstein, SC. 1985. Biochim Biophys Acta. 845: 204-15. PMID: 3838908
  14. Insulin binds to specific receptors and stimulates 2-deoxy-D-glucose uptake in cultured glial cells from rat brain.  |  Clarke, DW., et al. 1984. J Biol Chem. 259: 11672-5. PMID: 6384211
  15. Inhibition of doxorubicin-induced apoptosis in vivo by 2-deoxy-D-glucose.  |  Thakkar, NS. and Potten, CS. 1993. Cancer Res. 53: 2057-60. PMID: 8481907

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Deoxy-D-glucose, 1 g

sc-202010
1 g
$65.00

2-Deoxy-D-glucose, 5 g

sc-202010A
5 g
$210.00

Has this been used to treat glioblastoma?  If so, what result?

Asked by: Bobert
This chemical is for research use only. It is not intended for diagnostic or therapeutic use.
Answered by: Technical Support
Date published: 2021-12-09

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-202425, is provided as a white to off-white crystalline powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-17

The compound turns to a yellow solution instead of a normal white solution upon dissolving in water. Does the color affect its quality?

Asked by: two2igm05
Thank you for your question. This particular compound has a different color with each batch. The difference in color from lot-to-lot does not affect its performance, it is just an effect of the production process. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2016-12-16
  • y_2025, m_8, d_27, h_5CST
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Rated 5 out of 5 by from No complaints about this productNo complaints about this product. Used in cancer cell line.
Date published: 2015-09-04
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2-Deoxy-D-glucose is rated 5.0 out of 5 by 2.
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