Molecular structure of 2-Deoxy-2-fluoro-L-fucose, CAS Number: 70763-62-1
2-Deoxy-2-fluoro-L-fucose (CAS 70763-62-1)
See product citations (4)
Alternate Names:
2-Deoxy-2-fluoro-L-fucose is also known as 2FF.
Application:
2-Deoxy-2-fluoro-L-fucose is a monosaccharide that Reduces fucosylation of IgG in antibodies, increasing therapeutic efficacy.
CAS Number:
70763-62-1
Purity:
≥98%
Molecular Weight:
166.15
Molecular Formula:
C6H11FO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2-Deoxy-2-fluoro-L-fucose is a monosaccharide that can be metabolised inside the cell to a substrate-based inhibitor of fucosyltransferases. It can also be converted to GDP-2-deoxy-2-fluoro-L-fucose, a competitive inhibitor of α-1,3-fucosyltransferase. Since 2-Deoxy-2-fluoro-L-fucose reduces fucosylation of IgG in antibodies, it therefore increases therapeutic efficacies of antibodies that cause antibody-dependent cellular cytotoxicity. 2-Deoxy-2-fluoro-L-fucose is also known as 2FF, and 2,6-dideoxy-2-fluoro-L-galactose.
2-Deoxy-2-fluoro-L-fucose (CAS 70763-62-1) References
- High Yield Expression of Recombinant Human Proteins with the Transient Transfection of HEK293 Cells in Suspension. | Subedi, GP., et al. 2015. J Vis Exp. e53568. PMID: 26779721
- Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase. | Allen, JG., et al. 2016. ACS Chem Biol. 11: 2734-2743. PMID: 27434622
- Multi-level glyco-engineering techniques to generate IgG with defined Fc-glycans. | Dekkers, G., et al. 2016. Sci Rep. 6: 36964. PMID: 27872474
- Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities. | Dekkers, G., et al. 2017. Front Immunol. 8: 877. PMID: 28824618
- Fucosylated Molecules Competitively Interfere with Cholera Toxin Binding to Host Cells. | Wands, AM., et al. 2018. ACS Infect Dis. 4: 758-770. PMID: 29411974
- Antibody glycoengineering strategies in mammalian cells. | Wang, Q., et al. 2018. Biotechnol Bioeng. 115: 1378-1393. PMID: 29457629
- Synthesis and use of 6,6,6-trifluoro-L-fucose to block core-fucosylation in hybridoma cell lines. | McKenzie, NC., et al. 2018. Carbohydr Res. 465: 4-9. PMID: 29874559
- Virtual Screening Against Carbohydrate-Binding Proteins: Evaluation and Application to Bacterial Burkholderia ambifaria Lectin. | Dingjan, T., et al. 2018. J Chem Inf Model. 58: 1976-1989. PMID: 30075071
- Core-Fucosylated Tetra-Antennary N-Glycan Containing A Single N-Acetyllactosamine Branch Is Associated with Poor Survival Outcome in Breast Cancer. | Herrera, H., et al. 2019. Int J Mol Sci. 20: PMID: 31126011
- Chemoenzymatic synthesis of 3-deoxy-3-fluoro-l-fucose and its enzymatic incorporation into glycoconjugates. | Valverde, P., et al. 2020. Chem Commun (Camb). 56: 6408-6411. PMID: 32390019
- A streamlined pipeline for multiplexed quantitative site-specific N-glycoproteomics. | Fang, P., et al. 2020. Nat Commun. 11: 5268. PMID: 33077710
- Druggable Allosteric Sites in β-Propeller Lectins. | Shanina, E., et al. 2022. Angew Chem Int Ed Engl. 61: e202109339. PMID: 34713573
- Aberrant L-Fucose Accumulation and Increased Core Fucosylation Are Metabolic Liabilities in Mesenchymal Glioblastoma. | Pieri, V., et al. 2023. Cancer Res. 83: 195-218. PMID: 36409826
- 2-Deoxy-2-fluoro-L-fucose and its effect on L-[1-14C]fucose utilization in mammalian cells. | Winterbourne, DJ., et al. 1979. Biochem Biophys Res Commun. 87: 989-92. PMID: 572678
- Mechanism of human alpha-1,3-fucosyltransferase V: glycosidic cleavage occurs prior to nucleophilic attack. | Murray, BW., et al. 1997. Biochemistry. 36: 823-31. PMID: 9020780
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Deoxy-2-fluoro-L-fucose, 5 mg | sc-283123B | 5 mg | $170.00 | |||
2-Deoxy-2-fluoro-L-fucose, 10 mg | sc-283123 | 10 mg | $320.00 | |||
2-Deoxy-2-fluoro-L-fucose, 25 mg | sc-283123A | 25 mg | $785.00 | |||
2-Deoxy-2-fluoro-L-fucose, 50 mg | sc-283123C | 50 mg | $1464.00 | |||
2-Deoxy-2-fluoro-L-fucose, 100 mg | sc-283123D | 100 mg | $2820.00 |