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2-Deoxy-2-fluoro-D-glucose 6-Phosphate Dipotassium Salt (CAS 441764-08-5)

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Alternate Names:
Potassium ((2R,3S,4S,5R)-5-Fluoro-3,4,6-trihydroxytetrahydro-2H-pyran-2-yl)methyl Phosphate
CAS Number:
441764-08-5
Molecular Weight:
338.31
Molecular Formula:
C6H10FK2O8P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Deoxy-2-fluoro-D-glucose 6-phosphate dipotassium salt is a chemically modified glucose analog that serves as a compound in biochemical research, particularly in studies focused on glycolysis and glucose metabolism pathways. The introduction of a fluorine atom renders this compound uniquely valuable for probing the mechanisms of glucose uptake and phosphorylation within cells. This modification creates a molecule that, once phosphorylated, becomes trapped within the cell, making it an excellent tool for studying cellular glucose metabolism without further progression through the glycolytic pathway. By employing 2-deoxy-2-fluoro-D-glucose 6-phosphate dipotassium salt in research, scientists can investigate the intricacies of metabolic regulation, enzyme-substrate specificity, and the role of glucose metabolism in various states. This compound also aids in the exploration of metabolic flux through glycolytic pathways, offering a deeper understanding of how cells adapt their energy production strategies in response to different environmental and cellular conditions.


2-Deoxy-2-fluoro-D-glucose 6-Phosphate Dipotassium Salt (CAS 441764-08-5) References

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  2. Importance of specific hydrogen-bond donor-acceptor interactions for the key carbocycle-forming reaction catalyzed by 2-deoxy-scyllo-inosose synthase in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics.  |  Eguchi, T., et al. 2002. J Org Chem. 67: 3979-84. PMID: 12054929
  3. Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters.  |  Kang, SA., et al. 2019. Cell Chem Biol. 26: 1203-1213.e13. PMID: 31231029
  4. A quantitative LC-MS/MS approach for monitoring 2'-fluoro-2'-deoxy-D-glucose uptake in tumor tissue.  |  Li, W., et al. 2021. Bioanalysis. 13: 481-491. PMID: 33724050
  5. Effect of diet and also physiological state on some enzymes of carbohydrate metabolism in the liver of the domestic fowl.  |  Pearce, J. 1972. Biochem J. 130: 21P-22P. PMID: 4144073
  6. The deoxyfluoro-D-glucopyranose 6-phosphates and their effect on yeast glucose phosphate isomerase.  |  Bessell, EM. and Thomas, P. 1973. Biochem J. 131: 77-82. PMID: 4269121
  7. The effect of substitution at C-2 of D-glucose 6-phosphate on the rate of dehydrogenation by glucose 6-phosphate dehydrogenase (from yeast and from rat liver).  |  Bessell, EM. and Thomas, P. 1973. Biochem J. 131: 83-9. PMID: 4578852
  8. Some in vivo and in vitro antitumour effects of the deoxyfluoro-D-glucopyranoses.  |  Bessell, EM., et al. 1973. Eur J Cancer (1965). 9: 463-70. PMID: 4803223

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Deoxy-2-fluoro-D-glucose 6-Phosphate Dipotassium Salt, 2.5 mg

sc-500354
2.5 mg
$463.00