Molecular structure of 2-Demethyl Colchicine, CAS Number: 102491-80-5
2-Demethyl Colchicine (CAS 102491-80-5)
Application:
2-Demethyl Colchicine is a Colchicine metabolite
CAS Number:
102491-80-5
Molecular Weight:
385.41
Molecular Formula:
C21H23NO6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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2-Demethyl Colchicine is a metabolite of Colchicine, an alkaloid found the plant family Colchicaceae. It is a highly potent and selective inhibitor of tubulin polymerization and has been used in scientific research for its ability to interfere with cell division and microtubule formation. It binds to the colchicine binding site of the tubulin protein, which prevents the tubulin from forming microtubules. As a result, the cell cycle is disrupted and cell division is inhibited. 2-Demethyl Colchicine has been employed in a variety of applications, including cell cycle analysis and protein-protein interaction studies. It also shows anti-inflammatory and anti-tumor activity.
2-Demethyl Colchicine (CAS 102491-80-5) References
- Determination of colchicine and O-demethylated metabolites in decomposed skeletal tissues by microwave assisted extraction, microplate solid phase extraction and ultra-high performance liquid chromatography (MAE-MPSPE-UHPLC). | Watterson, JH., et al. 2014. J Chromatogr B Analyt Technol Biomed Life Sci. 960: 145-50. PMID: 24799069
- Comparison of Seeds of Colchicum speciosum and Gloriosa superba in respect to Colchicine and Colchicoside Contents by RP-LC. | Gumustas, M., et al. 2016. Nat Prod Commun. 11: 397-400. PMID: 27169190
- Tropolone alkaloids from Colchicum kurdicum (Bornm.) Stef. (Colchicaceae) as the potent novel antileishmanial compounds; purification, structure elucidation, antileishmanial activities and molecular docking studies. | Azadbakht, M., et al. 2020. Exp Parasitol. 213: 107902. PMID: 32353376
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Demethyl Colchicine, 10 mg | sc-206441 | 10 mg | $286.00 |