2-cyano-Pyrimidine CAS: 14080-23-0
MF: C5H3N3
MW: 105.10
A pyrimidine inhibitor of cathepsin K.

2-cyano-Pyrimidine (CAS 14080-23-0)

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Alternate Names: 2-pyrimidinecarbonitrile
Application: 2-cyano-Pyrimidine is a pyrimidine inhibitor of cathepsin K
CAS Number: 14080-23-0
Molecular Weight: 105.10
Molecular Formula: C5H3N3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

2-cyano-Pyrimidine is a cathepsin K inhibitor whose basic structure and subsequent derivatives are under study for the treatment of osteoperosis. Cathepsin K is a lysosomal cysteine protease found in osteoclasts. Elevated activity of this protease has been linked to the formation of osteoporosis and arthritis.


References

1 Altmann, E., Aichholz, R., Betschart, C., et al. 2-cyano-pyrimidines: A new chemotype for inhibitors of the cysteine protease cathepsin K. J Med Chem 50(4) 591-594 (2007). 2 Carroll, J., Smith, N., Babson, A.L. A colorimetric serum glucose determination using hexokinase and glucose-6-phosphate dehydrogenase. Biochem Med 4 171-180 (1970).

Physical State :
Solid
Solubility :
Soluble in ethanol (~20 mg/ml), DMSO (~20 mg/ml), DMF (~20 mg/ml), PBS, pH 7.2 (~3 mg/ml), and methanol.
Storage :
Store at -20° C
Melting Point :
40-44° C (lit.)
Boiling Point :
250.67° C at 760 mmHg (Predicted)
Density :
1.23 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
IC50 :
Cathepsin K: IC50 = 170 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
2757979
MDL Number :
MFCD00160513
Beilstein Registry :
109639
SMILES :
C1=CN=C(N=C1)C#N

Download SDS (MSDS)

Certificate of Analysis

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