Molecular structure of 2-Chloro-N6-cyclopentyladenosine, CAS Number: 37739-05-2
2-Chloro-N6-cyclopentyladenosine (CAS 37739-05-2)
Alternate Names:
CCPA
Application:
2-Chloro-N6-cyclopentyladenosine is a potent and selective Adenosine A1-R agonist
CAS Number:
37739-05-2
Molecular Weight:
369.81
Molecular Formula:
C15H20ClN5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2-Chloro-N6-cyclopentyladenosine is a potent and selective Adenosine A1-R agonist (Ki values are 0.8, 2300 and 42 nM for human Adenosine A1-R, Adenosine A2A-R and Adenosine A3-R receptors, respectively; EC50 = 18800 nM for human Adenosine A2B-R).
2-Chloro-N6-cyclopentyladenosine (CAS 37739-05-2) References
- Adenosine receptors and their ligands. | Klotz, KN. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362: 382-91. PMID: 11111832
- Release of atrial natriuretic factor induced by the A1 adenosine receptor agonist 2-chloro-N6-cyclopentyl-adenosine in the rat. | Massi, M., et al. 1992. Pharmacol Res. 25: 393-402. PMID: 1409251
- Highly selective A(1) -adenosine-agonist (2-chloro-N6-cyclopentyladenosine) and reduction of flap necrosis in adipocutaneous flaps in rats. | Dacho, AK., et al. 2012. Head Neck. 34: 1100-5. PMID: 22038887
- Adenosine A1 receptor activation attenuates lung ischemia-reperfusion injury. | Fernandez, LG., et al. 2013. J Thorac Cardiovasc Surg. 145: 1654-9. PMID: 23398646
- An adenosine A1 agonist 2-chloro-N6 cyclopentyladenosine inhibits the angiotensin II-induced cardiomyocyte hypertrophy through the calcineurin pathway. | Zhang, X., et al. 2014. Cardiology. 129: 153-62. PMID: 25277512
- Adenosine A1 Receptor Agonist 2-chloro-N6-cyclopentyladenosine and Hippocampal Excitability During Brain Development in Rats. | Fabera, P., et al. 2019. Front Pharmacol. 10: 656. PMID: 31258477
- 2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors. | Lohse, MJ., et al. 1988. Naunyn Schmiedebergs Arch Pharmacol. 337: 687-9. PMID: 3216901
- Pharmacology of the highly selective A1 adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine. | Monopoli, A., et al. 1994. Arzneimittelforschung. 44: 1305-12. PMID: 7848348
- Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain. | Concas, A., et al. 1993. J Pharmacol Exp Ther. 267: 844-51. PMID: 8246158
- Pretreatment with the adenosine A1 selective agonist, 2-chloro-N6-cyclopentyladenosine (CCPA), causes a sustained limitation of infarct size in rabbits. | Tsuchida, A., et al. 1993. Cardiovasc Res. 27: 652-6. PMID: 8324800
- Measurement of guanine nucleotide-binding protein activation by A1 adenosine receptor agonists in bovine brain membranes: stimulation of guanosine-5'-O-(3-[35S]thio)triphosphate binding. | Lorenzen, A., et al. 1993. Mol Pharmacol. 44: 115-23. PMID: 8341267
- 1,3-Dipropyl-8-[2-(5,6-epoxy)norbornyl]xanthine, a potent, specific and selective A1 adenosine receptor antagonist in the guinea pig heart and brain and in DDT1MF-2 cells. | Belardinelli, L., et al. 1995. J Pharmacol Exp Ther. 275: 1167-76. PMID: 8531078
- Adenosine activates ATP-sensitive potassium channels in arterial myocytes via A2 receptors and cAMP-dependent protein kinase. | Kleppisch, T. and Nelson, MT. 1995. Proc Natl Acad Sci U S A. 92: 12441-5. PMID: 8618917
- Interaction of full and partial agonists of the A1 adenosine receptor with receptor/G protein complexes in rat brain membranes. | Lorenzen, A., et al. 1996. Mol Pharmacol. 49: 915-26. PMID: 8622642
- Pharmacological interactions between magnesium ion and adenosine on monoaminergic system in the central nervous system. | Okada, M. and Kaneko, S. 1998. Magnes Res. 11: 289-305. PMID: 9884987
Activator of:
Adenosine A1-R, Adenosine A3-R, and NECAP 2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Chloro-N6-cyclopentyladenosine, 10 mg | sc-203460 | 10 mg | $138.00 | |||
2-Chloro-N6-cyclopentyladenosine, 50 mg | sc-203460A | 50 mg | $587.00 |