2-Chloro-N6-cyclopentyladenosine is a potent and selective Adenosine A1-R agonist (Ki values are 0.8, 2300 and 42 nM for human Adenosine A1-R, Adenosine A2A-R and Adenosine A3-R receptors, respectively; EC50 = 18800 nM for human Adenosine A2B-R).
1. Lohse, M.L., et al. 1988. Naunyn-Schmied. Arch. Pharmacol. 337: 687-689. PMID: 3216901 2. Concas, A., et al. 1993. J. Pharmacol. Exp. Ther. 267: 844-851. PMID: 8246158 3. Monopoli, A., et al. 1994. Arzneimittelforschung. 44: 1305-1312. PMID: 7848348 4. Klotz, K.N. 2000. Naunyn-Schmied. Arch. Pharmacol. 362: 382-391. PMID: 11111832
Soluble in water (5 mM), DMSO (100 mM), 0.1N HCI (12 mg/ml), and methanol (20 mg/ml).
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