2-Chloro-N6-cyclopentyladenosine CAS: 37739-05-2
MF: C15H20ClN5O4
MW: 369.81
A potent and selective Adenosine A1-R agonist.

2-Chloro-N6-cyclopentyladenosine (CAS 37739-05-2)

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Alternate Names: CCPA
Application: 2-Chloro-N6-cyclopentyladenosine is a potent and selective Adenosine A1-R agonist
CAS Number: 37739-05-2
Molecular Weight: 369.81
Molecular Formula: C15H20ClN5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

2-Chloro-N6-cyclopentyladenosine is a potent and selective Adenosine A1-R agonist (Ki values are 0.8, 2300 and 42 nM for human Adenosine A1-R, Adenosine A2A-R and Adenosine A3-R receptors, respectively; EC50 = 18800 nM for human Adenosine A2B-R).


References

1. Lohse, M.L., et al. 1988. Naunyn-Schmied. Arch. Pharmacol. 337: 687-689. PMID: 3216901
2. Concas, A., et al. 1993. J. Pharmacol. Exp. Ther. 267: 844-851. PMID: 8246158
3. Monopoli, A., et al. 1994. Arzneimittelforschung. 44: 1305-1312. PMID: 7848348
4. Klotz, K.N. 2000. Naunyn-Schmied. Arch. Pharmacol. 362: 382-391. PMID: 11111832

Physical State :
Solid
Solubility :
Soluble in water (5 mM), DMSO (100 mM), 0.1N HCI (12 mg/ml), and methanol (20 mg/ml).
Storage :
Store at room temperature
Melting Point :
258.03° C (Predicted)
Boiling Point :
617.31° C at 760 mmHg (Predicted)
Density :
1.88 g/cm3 (Predicted)
Refractive Index :
n20D 1.82 (Predicted)
IC50 :
hA2B: EC5050 = 18800 nM; Adenosine A1 receptor: IC50 = 1.3 nM (human); Adenosine A2a receptor: IC50 = 730 nM (rat); Adenylate cyclase type II: IC50 = 730 nM (rat); Adenosine A1 receptor: EC5050 = 8.2 nM (rat)
Ki Data :
adenosine A1 receptor: Ki= 0.8 nM (human); adenosine A2 receptor: Ki= 2300 nM (human); adenosine A3 receptor: Ki= 42 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
AU7357555
PubChem CID :
1547
MDL Number :
MFCD00078574
SMILES :
C1CCC(C1)NC2=NC(=NC3=C2N=CN3C4C(C(C(O4)CO)O)O)Cl

Download SDS (MSDS)

Certificate of Analysis

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