Molecular structure of 2-Bromohexadecanoic acid, CAS Number: 18263-25-7
2-Bromohexadecanoic acid (CAS 18263-25-7)
See product citations (4)
Alternate Names:
2-Bromopalmitic acid
Application:
2-Bromohexadecanoic acid is a PPARδ agonist
CAS Number:
18263-25-7
Molecular Weight:
335.32
Molecular Formula:
C16H31BrO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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2-Bromohexadecanoic acid is a PPARδ agonist that has also been shown to inhibit fatty acid oxidation, inhibit DHHC-mediated palmitoylation. 2-Bromohexadecanoic acid functions as an enzyme inhibitor by binding to the active sites of enzymes, thereby obstructing their catalytic activity. This inhibitory effect is attributed to the bromine atom present in the compound, which exhibits a heightened affinity for the enzyme′s active site when compared to other fatty acids.
2-Bromohexadecanoic acid (CAS 18263-25-7) References
- Raising flags: applications of chemical marker groups to study self-assembly, chirality, and orientation of interfacial films by scanning tunneling microscopy. | Giancarlo, LC. and Flynn, GW. 2000. Acc Chem Res. 33: 491-501. PMID: 10913238
- Extraction of bismuth(III) with 2-bromoalkanoic acid in nondonating solvent from highly acidic aqueous solution. | Moriya, Y., et al. 2001. Anal Sci. 17: 297-300. PMID: 11990544
- A new retinoid-like compound that activates peroxisome proliferator-activated receptors and lowers blood glucose in diabetic mice. | Deng, T., et al. 2005. Biol Pharm Bull. 28: 1192-6. PMID: 15997096
- Catalytic action of L-2-halo acid dehalogenase on long-chain L-2-haloalkanoic acids in organic solvents. | Hasan, AK., et al. 1991. Biotechnol Bioeng. 38: 1114-7. PMID: 18600877
- Protein palmitoylation regulates osteoblast differentiation through BMP-induced osterix expression. | Leong, WF., et al. 2009. PLoS One. 4: e4135. PMID: 19125191
- Pan-PPAR agonists based on the resveratrol scaffold: biological evaluation and docking studies. | Li, W., et al. 2010. ChemMedChem. 5: 1977-82. PMID: 20973122
- Fatty acid-induced nuclear translocation of heparanase uncouples glucose metabolism in endothelial cells. | Wang, F., et al. 2012. Arterioscler Thromb Vasc Biol. 32: 406-14. PMID: 22116097
- In Vitro and In Vivo Characterizations of Chiglitazar, a Newly Identified PPAR Pan-Agonist. | He, BK., et al. 2012. PPAR Res. 2012: 546548. PMID: 23150725
- 2'-(2-bromohexadecanoyl)-paclitaxel conjugate nanoparticles for the treatment of non-small cell lung cancer in an orthotopic xenograft mouse model. | Peng, L., et al. 2014. Int J Nanomedicine. 9: 3601-10. PMID: 25114529
- Length of hydrocarbon chain influences location of curcumin in liposomes: Curcumin as a molecular probe to study ethanol induced interdigitation of liposomes. | El Khoury, E. and Patra, D. 2016. J Photochem Photobiol B. 158: 49-54. PMID: 26945646
- Targeting protein palmitoylation decreases palmitate‑induced sphere formation of human liver cancer cells. | Chong, LW., et al. 2020. Mol Med Rep. 22: 939-947. PMID: 32468006
- Bioassay-Guided Isolation of Anthelmintic Components from Semen pharbitidis, and the Mechanism of Action of Pharbitin. | Liu, M., et al. 2022. Int J Mol Sci. 23: PMID: 36555386
Inhibitor of:
ACBD5, ACOXL, ACSVL5, ARA160, caveolin-2, DCST1, DPPL2, FAM57B, HADHB, NGL-1, OR6B1, PAM, Peroxin 16, Peroxin 19, RFFL, SSEA-4, TM4SF4, TPRX1, TSPAN3, ZDHHC, ZDHHC1, ZDHHC11, ZDHHC11B, ZDHHC12, ZDHHC14, ZDHHC15, ZDHHC16, ZDHHC19, ZDHHC24, ZDHHC5, ZDHHC6, ZDHHC8, ZNF184, and ZXDC.Activator of:
GODZ, PPAR beta, RAM, TMEM34, ZDHHC14, ZDHHC25, and ZDHHC4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Bromohexadecanoic acid, 10 g | sc-251714 | 10 g | $53.00 | |||
2-Bromohexadecanoic acid, 50 g | sc-251714A | 50 g | $201.00 |