Molecular structure of 2-Bromoaldisine, CAS Number: 96562-96-8
2-Bromoaldisine (CAS 96562-96-8)
Alternate Names:
2-Bromo-6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione
Application:
2-Bromoaldisine is an inhibitor of the Raf/MEK-1/MAPK cascade
CAS Number:
96562-96-8
Purity:
≥96%
Molecular Weight:
243.1
Molecular Formula:
C8H7BrN2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
2-Bromoaldisine is an inhibitor of the Raf/MEK-1/MAPK cascade (IC50= 539nM).
2-Bromoaldisine (CAS 96562-96-8) References
Marine natural products: pyrrololactams from several sponges: F.J. Schmitz, et al.; J. Nat. Prod. 48, 47 (1985) Total syntheses of hymenialdisine and debromohymenialdisine: Stereospecific construction of the 2-amino-4-oxo-2-imidazolin-5(Z)-disubstituted y ylidene ring system: H. Annoura & T. Tatsuoka; THL 36, 413 (1995) Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1): D. Tasdemir, et al.; J. Med. Chem. 45, 529 (2002) Anti-Cancer Metabolites from Marine Sponges: D. Tasdemir; Biodiversity: Biomolecular Aspects of Biodiversity and Innovative Utilization 2002, 187 Synthesis and target identification of hymenialdisine analogs: Y. Wan, et al.; Chem. Biol. 11, 247 (2004) Novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella verrucosa: A. Aiello, et al.; Bioorg. Med. Chem. 14, 17 (2006) Stereoselective synthesis of (Z)-axino- and (Z)-debromoaxinohydantoin: F. Tutino, et al.; Tetrahedron 65, 2372 (2009)Inhibitor of:
MEK-1, Raf, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Bromoaldisine, 0.5 mg | sc-202880 | 0.5 mg | $77.00 |